Proceedings of the 2015 International conference on Applied Science and Engineering Innovation

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Synthesis of 7-(benzyloxy)-4-chloro-6-methoxyquinazoline

Authors
Min Wang, Ping Wang, Yiqiang OuYang, Linxiao Wang, Qingjun Li, Si Gao, Shan Xu
Corresponding Author
Min Wang
Available Online May 2015.
DOI
10.2991/asei-15.2015.422How to use a DOI?
Keywords
7-(Benzyloxy)-4-chloro-6-methoxyquinazoline;Vandetanib;Synthesis
Abstract

7-(Benzyloxy)-4-chloro-6-methoxyquinazoline(1) was synthesized from methyl 4-hydroxy-3-methoxybenzoate(2) through five steps including substitution,nitration,reduction,cyclization and chlorination.Its structure was confirmed by 1 H NMR and MS spectrum.The total yield of the five steps was 29.2%.

Copyright
© 2015, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the 2015 International conference on Applied Science and Engineering Innovation
Series
Advances in Engineering Research
Publication Date
May 2015
ISBN
10.2991/asei-15.2015.422
ISSN
2352-5401
DOI
10.2991/asei-15.2015.422How to use a DOI?
Copyright
© 2015, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - CONF
AU  - Min Wang
AU  - Ping Wang
AU  - Yiqiang OuYang
AU  - Linxiao Wang
AU  - Qingjun Li
AU  - Si Gao
AU  - Shan Xu
PY  - 2015/05
DA  - 2015/05
TI  - Synthesis of 7-(benzyloxy)-4-chloro-6-methoxyquinazoline
BT  - Proceedings of the 2015 International conference on Applied Science and Engineering Innovation
PB  - Atlantis Press
SP  - 2151
EP  - 2153
SN  - 2352-5401
UR  - https://doi.org/10.2991/asei-15.2015.422
DO  - 10.2991/asei-15.2015.422
ID  - Wang2015/05
ER  -