Recent Progress in High Shear Wet Granulation Process

DOI

10.2991/amsee-16.2016.11How to use a DOI?

Keywords

review; high shear granulation; wetting and nucleation; consolidation and growth; and breakage and attrition

Abstract

High shear wet granulation is widely used in the pharmaceutical industry, however it is still difficult to predict the results of granulation and explain the relevant results. The paper reviews the three key processes in high shear granulation: wetting and nucleation, consolidation and growth, and breakage and attrition, combines with the corresponding models, the dimensionless parameters, regime maps and related mechanisms. Summarizes the basis and methods for judgment of granulation endpoint of final product. And proposed future direction of development of granulation and research ideas, which helps to solve the existing problems in the production and accelerate its development.

Copyright

© 2016, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Ning Zhou
AU  - Liangshan Ming
AU  - Kai Li
AU  - Xiao Cheng
AU  - Zhe Li
PY  - 2016/04
DA  - 2016/04
TI  - Recent Progress in High Shear Wet Granulation Process
BT  - Proceedings of the 2016 International Conference on Advanced Materials Science and Environmental Engineering
PB  - Atlantis Press
SP  - 37
EP  - 40
SN  - 2352-5401
UR  - https://doi.org/10.2991/amsee-16.2016.11
DO  - 10.2991/amsee-16.2016.11
ID  - Zhou2016/04
ER  -