Volume 2, Issue 4, December 2009, Pages 375 - 385
Combining Resting-state fMRI and DTI Analysis for Early-onset Schizophrenia
Ming Ke, Hui Shen, Jintu Fan, Xing Huang, Zongtan Zhou, Xiaogang Chen, Dewen Hu
Received 27 December 2008, Accepted 18 September 2009, Available Online 1 December 2009.
- https://doi.org/10.2991/ijcis.2009.2.4.6How to use a DOI?
- Functional connectivity, Anatomical connectivity, Resting fMRI, Fractional anisotropy, Earlyonset schizophrenia
- We combined measures of resting-state functional magnetic resonance imaging and diffusion tensor imaging (DTI) to investigate alterations of function-structure relationships in patients with early-onset schizophrenia. DTI analysis revealed reduced fractional anisotropy in right frontal white matter. Corresponding gray matter regions showed reduced functional connectivity with other regions in the brain in patients with early-onset schizophrenia, compared with healthy controls. Our results demonstrated abnormal function-structure relationships in early-onset schizophrenia, and supported the view that white matter lesions might disrupt the neural circuits between frontal regions and other brain regions, and affect the functional connectivity in the frontal cortex.
- Open Access
- This is an open access article distributed under the CC BY-NC license.
Cite this article
TY - JOUR AU - Ming Ke AU - Hui Shen AU - Jintu Fan AU - Xing Huang AU - Zongtan Zhou AU - Xiaogang Chen AU - Dewen Hu PY - 2009 DA - 2009/12 TI - Combining Resting-state fMRI and DTI Analysis for Early-onset Schizophrenia JO - International Journal of Computational Intelligence Systems SP - 375 EP - 385 VL - 2 IS - 4 SN - 1875-6883 UR - https://doi.org/10.2991/ijcis.2009.2.4.6 DO - https://doi.org/10.2991/ijcis.2009.2.4.6 ID - Ke2009 ER -