Allogeneic Stem Cell Transplantation with a Novel Reduced Intensity Conditioning Regimen for the Treatment of Patients with Primary Cutaneous T-cell Lymphomas
- https://doi.org/10.2991/chi.k.210529.001How to use a DOI?
- Mycosis fungoides; sezary syndrome; cutaneous t-cell lymphomas; donor lymphocyte infusion; allogeneic stem cell transplantation; graft-versus-host disease; graft versus lymphoma
The prognosis of patients with mycosis fungoides (MF) and Sezary Syndrome (SS) varies greatly, from near normal life expectancy in patients with early stage, to a median survival of less than 2 years for those diagnosed with advanced stage disease. Initial response to treatment is almost always followed by relapse and, finally, most of patients enter a phase of advanced multi-drug resistant disease with a short life expectancy after multiple lines of treatment. Allogeneic stem cell transplantation (allo-SCT) is usually limited to patients with advanced disease resistant to multiple treatments. Retrospective registry-based studies have shown increased Non-relapse Mortality (NRM) rates in patients with poor performance status, as well as in patients treated with myeloablative conditioning regimens. Another major limitation of allo-SCT is the increased relapse rate which occurs in nearly 50% of the cases, and is probably due to the fact that only heavily pretreated patients with advanced disease are referred for allo-SCT. Due to the paucity of data, the ideal conditioning regimen which will provide the maximum therapeutic benefit without the cost of increased NRM is not currently known. In this article we present our experience with a novel regimen in the treatment of patients with advanced MF/SS.
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- Open Access
- This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - JOUR AU - Maria Stamouli AU - Konstantinos Gkirkas AU - Aggeliki Karagiannidi AU - Theodoros Iliakis AU - Spiros Chondropoulos AU - Thomas Thomopoulos AU - Vassiliki Nikolaou AU - Vassiliki Pappa AU - Evangelia Papadavid AU - Panagiotis Tsirigotis PY - 2021 DA - 2021/06/12 TI - Allogeneic Stem Cell Transplantation with a Novel Reduced Intensity Conditioning Regimen for the Treatment of Patients with Primary Cutaneous T-cell Lymphomas JO - Clinical Hematology International SP - 72 EP - 76 VL - 3 IS - 2 SN - 2590-0048 UR - https://doi.org/10.2991/chi.k.210529.001 DO - https://doi.org/10.2991/chi.k.210529.001 ID - Stamouli2021 ER -