The CD34+ Cell Dose Matters in Hematopoietic Stem Cell Transplantation with Peripheral Blood Stem Cells from Sibling Donors
- 10.2991/chi.d.200221.001How to use a DOI?
- Cell dose; CD34; HSCT; GVHD; PBSC
The effect of CD34+ cell dose in allogeneic hematopoietic stem cell transplantation (HSCT) on overall survival (OS) and incidence of acute and chronic graft-versus-host disease (GvHD) has not been established and few studies have been performed. Our single center analysis included 189 patients with hematological malignancies who received peripheral blood stem cell (PBSC) grafts from sibling donors. Myeloablative conditioning was used in 88 cases and 101 received reduced intensity conditioning. The median CD34+ cell dose was 5.6 × 106/kg (0.6–17.0). In the multivariate analysis, a CD34 cell dose of 6–7 × 106/kg was associated with better OS and lower transplant-related mortality (TRM), while a dose of <5 × 106/kg led to increased relapse and reduced chronic GVHD (cGVHD). A high CD34 cell-dose (>6.5 × 106/kg) correlated with less acute GVHD (aGVHD) II–IV. We conclude that the CD34 cell dose has an impact on the outcome of HSCT from sibling donor PBSCs.
- © 2020 International Academy for Clinical Hematology. Publishing services by Atlantis Press International B.V.
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TY - JOUR AU - M. Remberger AU - B. Grønvold AU - M. Ali AU - J. Mattsson AU - T. Egeland AU - K. U. Lundin AU - A. Myhre AU - I. Abrahamsen AU - D. Heldal AU - I. Dybedal AU - G. E. Tjønnfjord AU - T. Gedde-Dahl AU - Y. Fløisand PY - 2020 DA - 2020/03/04 TI - The CD34+ Cell Dose Matters in Hematopoietic Stem Cell Transplantation with Peripheral Blood Stem Cells from Sibling Donors JO - Clinical Hematology International SP - 74 EP - 81 VL - 2 IS - 2 SN - 2590-0048 UR - https://doi.org/10.2991/chi.d.200221.001 DO - 10.2991/chi.d.200221.001 ID - Remberger2020 ER -