Human Herpes Virus-6 Encephalitis Following Autologous Blood and Marrow Transplant
- 10.2991/chi.d.191123.001How to use a DOI?
- Encephalitis; Bone marrow transplant; Human herpes virus 6; Multiple myeloma
Human herpesvirus-6 (HHV-6) is a highly prevalent virus that establishes lifelong latency in human hosts. Symptomatic HHV-6 reactivation rarely occurs in immunocompetent individuals and is best described in immunosuppressed patients such as recipients of bone marrow transplants (BMT). In that setting, HHV-6 reactivation has been associated with fever, rash, pneumonitis, encephalitis, and delayed engraftment. While these complications are well documented in allogeneic transplant, the clinical impact of such reactivation is not well known in autologous BMT. We described a case of HHV-6-associated encephalitis in a previously heavily treated patient with multiple myeloma (MM) following a second autologous BMT, and discuss the need for clinicians to be aware of the potential clinical impact of HHV-6 following autologous BMT in the era of immunomodulatory agents.
- © 2019 International Academy for Clinical Hematology. Publishing services by Atlantis Press International B.V.
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- This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).
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TY - JOUR AU - Jacques Mario Azzi AU - Doyun Park AU - Maher Abdul-Hay AU - Kelli Cole AU - Frank Cirrone AU - Maxim Kreditor AU - A. Samer Al-Homsi PY - 2019 DA - 2019/11/28 TI - Human Herpes Virus-6 Encephalitis Following Autologous Blood and Marrow Transplant JO - Clinical Hematology International SP - 32 EP - 34 VL - 2 IS - 1 SN - 2590-0048 UR - https://doi.org/10.2991/chi.d.191123.001 DO - 10.2991/chi.d.191123.001 ID - Azzi2019 ER -