Artery Research

Volume 26, Issue Supplement 1, December 2020, Pages S77 - S77

P.55 Dietary Nitrate Prevents Progression of Carotid Subclinical Atherosclerosis Through BP-Independent Mechanisms in Patients with or at Risk of Type 2 Diabetes Mellitus: Results from the Double-Blind, Randomized-Controlled, Factorial Vasera Trial

Authors
Franca Morselli1, *, Luca Faconti1, Charlotte E Mills2, 3, Steve Morant4, Philip J Chowienczyk1, J Kennedy Cruickshank2, Andrew J Webb1, Alessandro Cavarape5
1King’s College London
2King’s College London, School of Life Course Sciences
3University of Reading, Department of Food and Nutritional Sciences, School of Chemistry, Food and Pharmacy
4Medicines Monitoring Unit (MEMO), University of Dundee
5Universita’ degli Studi di Udine
*Corresponding author. Email: franca.morselli@kcl.ac.uk
Corresponding Author
Franca Morselli
Available Online 31 December 2020.
DOI
10.2991/artres.k.201209.065How to use a DOI?
Keywords
Nitrate; intima-media thickness
Abstract

Background: Epidemiological and animal studies suggest the potential of dietary nitrate (NO 3) to inhibit atherogenesis. Spironolactone may improve arterial stiffness. We tested if 6 months’ intervention with dietary nitrate and spironolactone could affect carotid subclinical atherosclerosis and stiffness versus placebo/doxazosin, to control for blood pressure (BP), in a population with or at risk of type 2 diabetes [1].

Methods: A subgroup of participants in our double-blind, randomized-controlled, factorial VaSera trial were randomized to nitrate-containing beetroot juice or nitrate-depleted juice, and spironolactone or doxazosin. Ultrasound for carotid diameter (CD, mm) and intima-media thickness (CIMT, mm) was performed at baseline, 3- and 6-months.

Carotid stiffness (CS, m/s) was estimated from aortic pulse pressure (Arteriograph®) and carotid lumen area. Data was analysed by modified intention-to-treat and mixed-model effect, adjusted for confounders.

Results: 93 participants had a baseline evaluation; 86% had follow-up data. No statistical interactions occurred between the juice and drug arms. BP was similar between the juices and between the drugs. CIMT was significantly lower following nitrate-containing, compared with placebo juice [−0.06 (95% Confidence Interval −0.12, −0.01), p = 0.022], with no effect on CD. CS reduction was similar between juices [−0.38(−0.67, −0.10) with placebo, −0.13 (−0.42, 0.16) with active juice] and the drugs [−0.30(−0.58, −0.02) with doxazosin, −0.21(−0.51, 0.09), with spironolactone]. No differences were detected between spironolactone or doxazosin on CIMT and CD.

Conclusion: 6 months’ intervention with dietary nitrate influences vascular remodelling, but not carotid stiffness or diameter. Neither spironolactone nor doxazosin had a BP-independent effect on carotid structure and function.

Copyright
© 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Journal
Artery Research
Volume-Issue
26 - Supplement 1
Pages
S77 - S77
Publication Date
2020/12/31
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.2991/artres.k.201209.065How to use a DOI?
Copyright
© 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - JOUR
AU  - Franca Morselli
AU  - Luca Faconti
AU  - Charlotte E Mills
AU  - Steve Morant
AU  - Philip J Chowienczyk
AU  - J Kennedy Cruickshank
AU  - Andrew J Webb
AU  - Alessandro Cavarape
PY  - 2020
DA  - 2020/12/31
TI  - P.55 Dietary Nitrate Prevents Progression of Carotid Subclinical Atherosclerosis Through BP-Independent Mechanisms in Patients with or at Risk of Type 2 Diabetes Mellitus: Results from the Double-Blind, Randomized-Controlled, Factorial Vasera Trial
JO  - Artery Research
SP  - S77
EP  - S77
VL  - 26
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.201209.065
DO  - 10.2991/artres.k.201209.065
ID  - Morselli2020
ER  -