Artery Research

Volume 26, Issue Supplement 1, December 2020, Pages S48 - S48

P.25 Radial-Digital Pulse Wave Velocity: A Non-Invasive Method for Assessing Stiffness of Peripheral Small Arteries

Authors
Hasan Obeid1, 2, 3, 4, *, Charles-Antoine Garneau1, Catherine Fortier1, 2, 3, 4, Mathilde Pare1, Pierre Boutouyrie3, 4, Mohsen Agharazii1, 2
1Division of Nephrology, Department of Medicine, Faculty of Medicine, Université Laval
2CHU de Québec Research Center- L’Hôtel-Dieu de Québec Hospital
3INSERM, UMR-970, Paris Cardiovascular research Center
4AP-HP, Pharmacology Unit, Hôpital Européen Georges Pompidou, Université de Paris
*Corresponding author. Email: hasan.obeid90@gmail.com
Corresponding Author
Hasan Obeid
Available Online 31 December 2020.
DOI
10.2991/artres.k.201209.038How to use a DOI?
Keywords
Small arteries stiffness; microcirculation
Abstract

Pulse wave velocity (PWV) has been used to evaluate arterial stiffness of large arteries. Here, we examine the feasibility of radial-digital PWV (RD-PWV) as a measure of stiffness of smaller arteries, and its response to changes in local mean arterial pressure. In 29 healthy subjects, we used Complior probes to record arterial pulse wave at radial artery and tip of the index. To determine transit time, we used both second derivative and intersecting tangents of the entire recordings using the device-embedded algorithms, in house Matlab analyses of only reliable waves, and by numerical simulation using arterial tree model. In 15 subjects, we examine the response of RD-PWV to changes in local MAP by vertical displacement of the hand above and below the mid-axillary line. Using second derivative, RD-PWV were 4.68 ± 1.18, 4.69 ± 1.21, 4.32 ± 1.19 m/s respectively for device-embedded, Matlab-based and numerical simulation analyses, respectively. Using intersecting tangents RD-PWV were 4.73 ± 1.20, 4.45 ± 1.08, 4.50 ± 0.84 m/s, respectively for device-embedded, Matlab-based and numerical simulation analyses, respectively. The strongest correlation (r = 0.92) was seen between device-embedded and Matlab-based second derivatives. The intersession coefficients of variation were 7.0 ± 4.9% and 3.2 ± 1.9% (p = 0.04) for device-embedded and Matlab-based second derivative algorithms. We estimated that each increase of 10 mm Hg in local MAP by vertical displacement of the hand resulted in an increase in RD-PWV of 0.28 m/s. This study shows that RD-PWV can be used for the non-invasive assessment of stiffness of small-sized arteries.

Copyright
© 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Journal
Artery Research
Volume-Issue
26 - Supplement 1
Pages
S48 - S48
Publication Date
2020/12/31
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.2991/artres.k.201209.038How to use a DOI?
Copyright
© 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - JOUR
AU  - Hasan Obeid
AU  - Charles-Antoine Garneau
AU  - Catherine Fortier
AU  - Mathilde Pare
AU  - Pierre Boutouyrie
AU  - Mohsen Agharazii
PY  - 2020
DA  - 2020/12/31
TI  - P.25 Radial-Digital Pulse Wave Velocity: A Non-Invasive Method for Assessing Stiffness of Peripheral Small Arteries
JO  - Artery Research
SP  - S48
EP  - S48
VL  - 26
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.201209.038
DO  - 10.2991/artres.k.201209.038
ID  - Obeid2020
ER  -