P.32 Non-Invasive Measures of Arteriosclerosis Across Childhood and Adolescence: Insights Into the Natural History of Disease

Reeja Nasir; Tommy Ye Cai; Alice Meroni; Michael Skilton

doi:10.2991/artres.k.201209.045

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Volume 26, Issue Supplement 1, December 2020, Pages S55 - S55

P.32 Non-Invasive Measures of Arteriosclerosis Across Childhood and Adolescence: Insights Into the Natural History of Disease

Authors

Reeja Nasir¹^{, *}, Tommy Ye Cai¹^{, 2}, Alice Meroni¹, Michael Skilton¹

¹Boden Collaboration for Obesity, Nutrition, Exercise and Eating Disorders, University of Sydney

²Royal Prince Alfred Hospital

^*Corresponding author. Email: reeja.nasir@sydney.edu.au

Corresponding Author

Reeja Nasir

Available Online 31 December 2020.

DOI: 10.2991/artres.k.201209.045 How to use a DOI?
Keywords: Atherosclerosis; non-invasive; intima-media thickness
Abstract: Objectives: Non-invasive methodologies for assessing arteriosclerosis, including carotid intimal-medial thickness (cIMT) for assessing subclinical atherosclerosis and carotid-femoral pulse wave velocity (cfPWV) for measuring arterial stiffness, are well established and validated in adults [1, 2]. However, they are less well-described in children. Alternative methodologies, such as aortic IMT (aIMT), may be more appropriate in children provided the natural history of atherosclerotic disease [3]. Previous studies have predominantly applied these methodologies in a narrow age-range of children; methodological differences between studies make inter-study comparison of absolute values difficult. Therefore, we aimed to assess the severity of arteriosclerosis across childhood and adolescence using standardised application of age-appropriate and established methodologies.

Methods: We prospectively recruited 97 healthy children aged 2 to 20 (mean age = 11.2 ± 5.12 years old; stratified into five sex-balanced age groups). cIMT and aIMT were assessed via high-resolution B-mode ultrasonography. cfPWV was assessed via a semi-automated cuff-based device (Sphygmocor XCEL; AtCor Medical, Australia).

Results: aIMT increased with age (9 μm per year [95% CI: 6, 12], p < 0.0001), whereas cIMT did not meaningfully increase with age (2 μm per year [95% CI: −1, 5], p = 0.14). cfPWV remained relatively stable during early childhood, with an apparent increase from adolescence onwards.

Conclusions: Carotid and aortic atherosclerosis both increase throughout childhood, although this increase is greatest in the aorta. The aorta begins to stiffen during adolescence. Assessment of aortic arteriosclerosis is feasible in childhood and adolescence, and should be prioritised over assessment of carotid atherosclerosis in this age group.
Copyright: © 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

REFERENCES

[1]EM Urbina, RV Williams, BS Alpert, RT Collins, SR Daniels, L Hayman, et al., Noninvasive assessment of subclinical atherosclerosis in children and adolescents: recommendations for standard assessment for clinical research: a scientific statement from the American Heart Association, Hypertension, Vol. 54, 2009, pp. 919-50.

[2]RR Townsend, IB Wilkinson, EL Schiffrin, AP Avolio, JA Chirinos, JR Cockcroft, et al., Recommendations for Improving and Standardizing Vascular Research on Arterial Stiffness: A Scientific Statement From the American Heart Association, Hypertension, Vol. 66, 2015, pp. 698-722.

[3]MR Skilton, DS Celermajer, E Cosmi, F Crispi, SS Gidding, OT Raitakari, et al., Natural history of atherosclerosis and abdominal aortic intima-media thickness: rationale, evidence, and best practice for detection of atherosclerosis in the young, J Clin Med, 2019, pp. 8.

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Journal: Artery Research
Volume-Issue: 26 - Supplement 1
Pages: S55 - S55
Publication Date: 2020/12/31
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.2991/artres.k.201209.045 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

ris enw bib

TY  - JOUR
AU  - Reeja Nasir
AU  - Tommy Ye Cai
AU  - Alice Meroni
AU  - Michael Skilton
PY  - 2020
DA  - 2020/12/31
TI  - P.32 Non-Invasive Measures of Arteriosclerosis Across Childhood and Adolescence: Insights Into the Natural History of Disease
JO  - Artery Research
SP  - S55
EP  - S55
VL  - 26
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.201209.045
DO  - 10.2991/artres.k.201209.045
ID  - Nasir2020
ER  -

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