P.34 Preeclampsia Leads to the Delayed Development of Sympathetic Control of the Cardiovascular System in the Offspring

Ekaterina Selivanova; Anastasia Shvetsova; Victoria Potekhina; Dina Gaynullina; Anna Borzykh; Oxana Kiryukhina; Vladislav Kuzmin; Olga Tarasova

doi:10.2991/artres.k.201209.047

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Volume 26, Issue Supplement 1, December 2020, Pages S57 - S57

P.34 Preeclampsia Leads to the Delayed Development of Sympathetic Control of the Cardiovascular System in the Offspring

Authors

Ekaterina Selivanova¹^{, *}, Anastasia Shvetsova¹, Victoria Potekhina¹, Dina Gaynullina¹, Anna Borzykh², Oxana Kiryukhina³, Vladislav Kuzmin¹, Olga Tarasova¹

¹Lomonosov Moscow State University

²SRC RF IBMP RAS

³IITP RAS

^*Corresponding author. Email: blamanche@ya.ru

Corresponding Author

Ekaterina Selivanova

Available Online 31 December 2020.

DOI: 10.2991/artres.k.201209.047 How to use a DOI?
Keywords: preeclampsia; hypertension; intrauterine programming
Abstract: Background: Preeclampsia is a common pregnancy disease characterized by hypertension and kidney failure. Recent studies have shown that even in the case of successful delivery, preeclampsia could induce long-term effects in the offspring. Nevertheless, the effects of preeclampsia on the cardiovascular system of the offspring are poorly studied.

Methods: We induced preeclampsia in pregnant rats by L-NAME (nitric oxide synthase inhibitor) supplementation (250 mg/l in drinking water from gestation day 10 to delivery, daily dose 39 mg/kg). The model was verified by the dam’s blood pressure (BP) elevation (tail-cuff) and creatinine clearance reduction (metabolic cages) compared to control dams. Male offspring 16-18-day old were used for BP recording (catheter technique under urethane anesthesia); their isolated arteries were studied by wire myography. Adrenergic nerve plexus was visualized by glyoxylic acid staining.

Results: Offspring of dams with preeclampsia had reduced body weight compared to control. They also demonstrated decreased BP (43.3 ± 1.9 vs 50.5 ± 1.4 mmHg) and diminished response to the ganglionic blocker chlorizondamine (2.5 mg/kg); heart rate didn’t differ between the groups. The density of the sympathetic innervation of the right atrium and the saphenous artery was reduced in the preeclampsia offspring. Saphenous arteries from preeclampsia offspring had smaller diameter (276 ± 5 vs. 296 ± 7 micron) and maximal contraction force (9.4 ± 0.4 vs. 10.6 ± 0.4 mN) compared to control.

Conclusions: Preeclampsia is followed by the delay in sympathetic nervous system development in the offspring, which is accompanied by structural and functional alterations in the cardiovascular system.

The research was supported by Russian Science Foundation (Grant N 19-15-00210).
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Journal: Artery Research
Volume-Issue: 26 - Supplement 1
Pages: S57 - S57
Publication Date: 2020/12/31
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.2991/artres.k.201209.047 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

ris enw bib

TY  - JOUR
AU  - Ekaterina Selivanova
AU  - Anastasia Shvetsova
AU  - Victoria Potekhina
AU  - Dina Gaynullina
AU  - Anna Borzykh
AU  - Oxana Kiryukhina
AU  - Vladislav Kuzmin
AU  - Olga Tarasova
PY  - 2020
DA  - 2020/12/31
TI  - P.34 Preeclampsia Leads to the Delayed Development of Sympathetic Control of the Cardiovascular System in the Offspring
JO  - Artery Research
SP  - S57
EP  - S57
VL  - 26
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.201209.047
DO  - 10.2991/artres.k.201209.047
ID  - Selivanova2020
ER  -

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