YI 2.4 Neural Baroreflex Sensitivity and Long-Term Effect of Antihypertensive Agents—A Pharmacological Substudy of the Paris Prospective Study III

Nicolas Danchin; Catherine Guibout; Xavier Jouven; Marie-Cécile Perier; Frederique Thomas; Catherine Fortier; Jean-Philippe Empana; Hakim Khettab; Rosa-Maria Bruno; Pierre Boutouyrie

doi:10.2991/artres.k.201209.012

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Volume 26, Issue Supplement 1, December 2020, Pages S17 - S17

YI 2.4 Neural Baroreflex Sensitivity and Long-Term Effect of Antihypertensive Agents—A Pharmacological Substudy of the Paris Prospective Study III

Authors

Nicolas Danchin⁵, Catherine Guibout³^{, 4}, Xavier Jouven³^{, 4}, Marie-Cécile Perier³^{, 4}, Frederique Thomas⁵, Catherine Fortier¹^{, *}, Jean-Philippe Empana³^{, 4}, Hakim Khettab², Rosa-Maria Bruno¹^{, 2}, Pierre Boutouyrie¹^{, 2}

¹INSERM, U970, Paris Cardiovascular Research Center, Cellular molecular and physiological mechanisms of heart failure (Team 7)

²AP-HP, Pharmacology Unit, Hôpital Européen Georges Pompidou, Université de Paris

³INSERM U970, Paris Cardiovascular Research Centre (PARCC), University of Paris

⁴INSERM U970, Paris Cardiovascular Research Centre (PARCC), Integrative Epidemiology of Cardiovascular Disease (Team 4)

⁵Preventive and Clinical Investigation Center (IPC)

^*Corresponding author. Email: catherine.fortier@inserm.f

Corresponding Author

Catherine Fortier

Available Online 31 December 2020.

DOI: 10.2991/artres.k.201209.012 How to use a DOI?
Keywords: Antihypertensive; baroreflex; arterial stiffness
Abstract: Background/Objectives: The baroreflex is a crucial mechanism acutely modulating vascular tone and heart rate response to maintain blood pressure (BP) in an optimal range. A decrease in baroreflex sensitivity (BRS) is associated with ageing, and pathological conditions such as hypertension and diabetes. Antihypertensive agents are generally known to have beneficial effect on the BRS, however it is still uncertain if the effect is mediated through a more compliant arterial wall or a sympathoinhibitory action.

Methods: In the Paris Prospective Study III [1], spontaneous baroreflex, carotid stiffness and pharmacological drugs intake were available in 7967 adults (aged 55–75 years). The neural component of the baroreflex sensitivity (nBRS) was obtained with a cross-spectral analysis of variations in carotid distention rate and R-R intervals. Pharmacological classes were analysed according to the Anatomical Therapeutic Chemical (ATC) classification. Individuals with a BP lowering medication (BP-treated) were paired to non-BP treated individuals with a similar cardiovascular risk (controls) using a propensity score matching procedure (n = 1182 pairs).

Results: Amongst pharmacological classes of BP lowering agents, only agents acting on the renin-angiotensin system (ACEi-ARB) were associated with nBRS (β = –0.08, p = 0.045). Compared to their matched controls, ACEi-ARB users had lower nBRS (2.79 ± 0.66 vs. 2.90 ± 0.62, p = 0.03). In multivariate analysis, ACEi-ARB remained significant (stdβ = –0.09, p = 0.025) after adjustment for carotid stiffness (stdβ = 0.25, p < 0.001) and systolic pressure (stdβ = –0.20, p < 0.001).

Conclusion: In this epidemiological study, ACEi-ARB were negatively associated with nBRS. This effect is independent of BP and stiffness, which may suggest an inhibition of sympathetic activity by ACEi-ARB.
Copyright: © 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

REFERENCE

[1]JP Empana, K Bean, C Guibout, F Thomas, A Bingham, B Pannier, et al., Paris Prospective Study III: a study of novel heart rate parameters, baroreflex sensitivity and risk of sudden death, Eur J Epidemiol, Vol. 26, 2011, pp. 887-92.

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Journal: Artery Research
Volume-Issue: 26 - Supplement 1
Pages: S17 - S17
Publication Date: 2020/12/31
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.2991/artres.k.201209.012 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

ris enw bib

TY  - JOUR
AU  - Nicolas Danchin
AU  - Catherine Guibout
AU  - Xavier Jouven
AU  - Marie-Cécile Perier
AU  - Frederique Thomas
AU  - Catherine Fortier
AU  - Jean-Philippe Empana
AU  - Hakim Khettab
AU  - Rosa-Maria Bruno
AU  - Pierre Boutouyrie
PY  - 2020
DA  - 2020/12/31
TI  - YI 2.4 Neural Baroreflex Sensitivity and Long-Term Effect of Antihypertensive Agents—A Pharmacological Substudy of the Paris Prospective Study III
JO  - Artery Research
SP  - S17
EP  - S17
VL  - 26
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.201209.012
DO  - 10.2991/artres.k.201209.012
ID  - Danchin2020
ER  -

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