1.4 BLOOD PRESSURE LEVELS ARE THE SOLE DETERMINANT OF DIFFUSE MYOCARDIAL FIBROSIS IN HYPERTENSIVE PATIENTS

D. Rosenbaum; N. Kachenoura; A. Redheuil; A. Decesare; F. Villeneuve; X. Girerd; P. Cluzel

doi:10.1016/j.artres.2013.10.005

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Volume 7, Issue 3-4, September 2013, Pages 162 - 162

1.4 BLOOD PRESSURE LEVELS ARE THE SOLE DETERMINANT OF DIFFUSE MYOCARDIAL FIBROSIS IN HYPERTENSIVE PATIENTS

Authors

D. Rosenbaum¹^{, 2}, N. Kachenoura², A. Redheuil², A. Decesare², F. Villeneuve¹, X. Girerd¹, P. Cluzel²^{, 3}

¹Cardiovascular Prevention Unit, Pitié salpêtrière Hospital, Paris, France

²Laboratoire d’imagerie Fonctionnelle, UPMC INSERM U 678, Paris, France

³Département d’imagerie Cardiovasculaire, Pitié Salpêtrière Hospital, Paris, France

Available Online 11 November 2013.

DOI: 10.1016/j.artres.2013.10.005 How to use a DOI?
Abstract: Objectives. Myocardial fibrosis occurs early in hypertension and plays a major role in CV disease. Our goal was to assess the mutual influence of blood pressure (BP) and cardiovascular (CV) risk factors on diffuse myocardial fibrosis, as assessed non-invasively from Cardiovascular Magnetic Resonance (CMR) T1 mapping images in a population of non-diabetic hypertensive patients in primary prevention.

Methods. CMR MOLLI T1 mapping sequence was acquired on a median LV slice pre-contrast and then at 5, 10 and 15 minutes after a bolus injection of Gadolinium (0.2 mml/kg). After T1 estimation in myocardium and LV cavity, myocardial ECV was calculated as =(1 − hematocrit) × (1/T1post − 1/T1pre) myo / (1/T1post − 1/T1pre) blood. Patients also underwent routine clinical and biological assessments and BP levels were determined using 3 days home measurements (hBP).

Results. 37 patients (median age 57, range 31 to 71, 54% males) were included. Population characteristics are summarized in table 1. Mean ECV remained unchanged at 5, 10 and 15 minutes (0.21 ± 0.04). In univariate analysis, ECV was significantly associated with systolic hBP (r = 0.48, p = 0.017) but not with other risk factors (LDL-C, Hba1c, smoking status). This association remained significant after adjustment for age and hBP remained the only significant determinant of changes in ECV.

Conclusion. In hypertensive patients, home BP levels were found to be the sole significant and independent determinant of myocardial fibrosis.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 7 - 3-4
Pages: 162 - 162
Publication Date: 2013/11/11
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2013.10.005 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - D. Rosenbaum
AU  - N. Kachenoura
AU  - A. Redheuil
AU  - A. Decesare
AU  - F. Villeneuve
AU  - X. Girerd
AU  - P. Cluzel
PY  - 2013
DA  - 2013/11/11
TI  - 1.4 BLOOD PRESSURE LEVELS ARE THE SOLE DETERMINANT OF DIFFUSE MYOCARDIAL FIBROSIS IN HYPERTENSIVE PATIENTS
JO  - Artery Research
SP  - 162
EP  - 162
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.005
DO  - 10.1016/j.artres.2013.10.005
ID  - Rosenbaum2013
ER  -

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