Artery Research

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Volume 7, Issue 3-4, September 2013, Pages 160 - 160

P6.24 CLINICAL FEASIBILITY OF THE NEW PULSE TIME INDEX OF NORM (PTIN) AND ITS CORRELATION TO LEFT VENTRICULAR MASS INDEX

Authors
I.N. Posokhov1, J. Baulmann2, Z.D. Kobalava3, Y.V. Kotovskaya3, A.O. Konradi4, E.V. Shlyakhto4, O.V. Mamontov4, V.A. Korneva5, T.Y. Kuznetsova5, N.N. Kulikova6, I.V. Starchenkova6, E.A. Grigoricheva7, V.V. Evdokimov7, A.V. Orlov8, A.N. Rogoza8
1Hemodynamic Laboratory Ltd, Nizhniy Novgorod, Russian Federation
2Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Med. Klinik II, Lübeck, Germany
3People’s Friendship University of Russia, Medical Faculty, Moscow, Russian Federation
4Almazov Federal Heart, Blood and Endocrinology Centre, Saint-Petersburg, Russian Federation
5Petrozavodsk State University, Petrozavodsk, Russian Federation
63rd Republican Hospital, Saransk, Russian Federation
7Chelyabinsk State Medical Academy, Chelyabinsk, Russian Federation
8Cardiology Research Center, Moscow, Russian Federation
Available Online 11 November 2013.
DOI
10.1016/j.artres.2013.10.205How to use a DOI?
Abstract

Background: Recently the pulse wave velocity (PWV) threshold of hypertensive target organ damage (TOD) was set at 10 m/s. New 24 – h monitors (e.g., BPLab-Vasotens) provide not only 1 PWV but several PWV measurements over a 24 – h period. The new Pulse Time Index of Norm (PTIN) can be calculated from these data. The PTIN is defined as the percentage of a 24 – h period during which the PWV does not exceed 10 m/s. The idea is to adopt the new PWV measurements for the definition of TOD and sharpen its level of detection. The aim of the present study is to test the new PTIN for clinical feasibility and its correlation to left ventricular mass index (LVMI).

Methods: Oscillometrically generated waveform files (n=510, measurements ranging from a single point to 72 hours), which were previously used for clinical research, were re-analysed using the new 2013 software version of the Vasotens technology program, which enables PTIN calculation.

Results: The cut-off point at 10 m/s in the ROC curve showed a sensitivity of 93.3% and a specificity of 81.5% for single measurements of PWV compared to SphygmoCor. The reference interval of PTIN was equal to 83.2% (lower limit). Reliability statistics showed Cronbach’s alpha was 0.967 for day-to-day repeatability (i.e., excellent internal consistency of PTIN). Good correlation (r=−0.72) between PTIN and LVMI was shown, and it was significantly above the blood pressure load (r=0.41).

Conclusion: Calculating PTIN from Vasotens technology is clinically feasible and seems to enhance the discriminatory power of detecting TOD.

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This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
7 - 3-4
Pages
160 - 160
Publication Date
2013/11/11
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2013.10.205How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - I.N. Posokhov
AU  - J. Baulmann
AU  - Z.D. Kobalava
AU  - Y.V. Kotovskaya
AU  - A.O. Konradi
AU  - E.V. Shlyakhto
AU  - O.V. Mamontov
AU  - V.A. Korneva
AU  - T.Y. Kuznetsova
AU  - N.N. Kulikova
AU  - I.V. Starchenkova
AU  - E.A. Grigoricheva
AU  - V.V. Evdokimov
AU  - A.V. Orlov
AU  - A.N. Rogoza
PY  - 2013
DA  - 2013/11/11
TI  - P6.24 CLINICAL FEASIBILITY OF THE NEW PULSE TIME INDEX OF NORM (PTIN) AND ITS CORRELATION TO LEFT VENTRICULAR MASS INDEX
JO  - Artery Research
SP  - 160
EP  - 160
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.205
DO  - 10.1016/j.artres.2013.10.205
ID  - Posokhov2013
ER  -