Artery Research

Volume 7, Issue 3-4, September 2013, Pages 159 - 159

P6.19 PHYSIOLOGICAL CORRELATES OF AORTIC RESERVOIR AND EXCESS PRESSURE IN MAN

Authors
M.G. Schultz1, J.E. Davies2, A. Hardikar3, S. Pitt3, A.D. Hughes2, J.E. Sharman1
1Menzies Research Institute Tasmania, University of Tasmania, Hobart, Australia
2International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College London, London, United Kingdom
3Royal Hobart Hospital, Hobart, Australia
Available Online 11 November 2013.
DOI
10.1016/j.artres.2013.10.200How to use a DOI?
Abstract

Background: Central (aortic) blood pressure (BP) indices independently predict cardiovascular events and all-cause mortality, but the physiological mechanisms underlying aortic BP waveform morphology are subject to debate. The ‘aortic reservoir’ and ‘excess pressure’ are proposed as determinants of aortic BP, but this relationship has only been assessed using a mathematically-derived aortic reservoir-excess pressure model (ARderived and XPderived). This study aimed to directly measure the aortic reservoir (ARdirect; by cyclic change in aortic volume) and determine the relationship with ARderived and aortic BP.

Methods: Ascending aortic BP and Doppler flow velocity were recorded via intra-arterial wire in 10 males (aged 62±12 years) during coronary artery bypass graft surgery. Simultaneous ascending aortic transesophageal echocardiography was used to measure ARdirect. Published mathematical formulae were used to determine ARderived and XPderived. A direct excess pressure (XPdirect) was calculated by subtracting ARdirect from aortic BP.

Results: When normalised to the same scale (Figure A), ARdirect (solid line) was strongly and linearly related to ARderived (broken line) during systole (r=0.980, P<0.001, Figure B, point 1–2) and diastole (r=0.987, P<0.001 Figure B, point 2–3). The cyclic relationship between aortic BP and ARdirect was qualitatively and quantitatively (P>0.05) similar to the cyclic relationship between aortic BP and ARderived. Furthermore, XPdirect was linearly related to XPderived during systole (r=0.909, P<0.001) and diastole (r=0.663, P<0.001).

Conclusion: Aortic reservoir and excess pressures are physiological phenomena highly related to mathematically-derived aortic reservoir, excess pressure and aortic BP.

Open Access
This is an open access article distributed under the CC BY-NC license.

Journal
Artery Research
Volume-Issue
7 - 3-4
Pages
159 - 159
Publication Date
2013/11/11
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2013.10.200How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - M.G. Schultz
AU  - J.E. Davies
AU  - A. Hardikar
AU  - S. Pitt
AU  - A.D. Hughes
AU  - J.E. Sharman
PY  - 2013
DA  - 2013/11/11
TI  - P6.19 PHYSIOLOGICAL CORRELATES OF AORTIC RESERVOIR AND EXCESS PRESSURE IN MAN
JO  - Artery Research
SP  - 159
EP  - 159
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.200
DO  - 10.1016/j.artres.2013.10.200
ID  - Schultz2013
ER  -