P5.14 HIGH INTENSITY AEROBIC EXERCISE IN PATIENTS WITH ANKYLOSING SPONDYLITIS REDUCES ARTERIAL STIFFNESS: RESULTS FROM A RANDOMIZED CONTROLLED TRIAL

DOI

10.1016/j.artres.2013.10.163How to use a DOI?

Abstract

Objective: Patients with ankylosing spondylitis (AS) are at increased risk of CVD. The etiological mechanism or how to reduce risk is not known. Exercise can reduce CV risk in the general population. The objective was to test whether high intensity aerobic exercise reduces central arterial stiffness.

Methods: A proof of concept randomized controlled pilot study. AS patients were allocated to exercise group (EG) or control group (CG). The 3 months exercise intervention consisted of aerobic high intensity training 40 minutes 3 days a week and muscular strength training 20 minutes twice a week. The control group received care as usual. Augmentation Index (AIx) and pulse wave velocity (PWV) were assessed at baseline and after intervention. Statistical analyses (SPSS 20) were performed using Mann-Whitney U test to compare median change (from baseline to 3 months) of the parameters between EG and CG. Analyses were performed pr protocol.

Results: 28 AS patients were recruited, 24 patients fulfilled the study, 10 in the EG and 14 in the CG. There were some differences in demographics (EG vs. CG): age, years [median (min-max)] 43 (30–67) vs. 50 (26–68), male gender: 20% vs. 71%. After the study period, arterial stiffness was reduced in the EG compared CG, both significant for AIx (%) median (min-max) −3.3 (−24.5−2.5) vs. 1.7 (−13.5−10.3), p=0.04 and for PWV (m/s) median (min-max) −0.4 (−1.9−0.1) vs. −0.1 (−1.5−0.1), p=0.05 (figure).

Conclusion: Intervention with high intensity aerobic exercise in AS patients reduced arterial stiffness after 3 months compared to controls.

Open Access

This is an open access article distributed under the CC BY-NC license.

TY  - JOUR
AU  - I.J. Berg
AU  - A.G. Semb
AU  - S. Halvorsen
AU  - C. Fongen
AU  - T.K. Kvien
AU  - H. Dagfinrud
AU  - S.A. Provan
PY  - 2013
DA  - 2013/11/11
TI  - P5.14 HIGH INTENSITY AEROBIC EXERCISE IN PATIENTS WITH ANKYLOSING SPONDYLITIS REDUCES ARTERIAL STIFFNESS: RESULTS FROM A RANDOMIZED CONTROLLED TRIAL
JO  - Artery Research
SP  - 147
EP  - 148
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.163
DO  - 10.1016/j.artres.2013.10.163
ID  - Berg2013
ER  -