Artery Research

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Volume 7, Issue 3-4, September 2013, Pages 146 - 146

P5.10 MAJOR BRACHIAL-TO-RADIAL-SYSTOLIC-BLOOD-PRESSURE-AMPLIFICATION OCCURS IN HEALTHY PEOPLE AND IS SIGNIFICANTLY INCREASED WITH AGE

Authors
D.S. Picone1, R.E.D. Climie1, K.D.K. Ahuja2, M.A. Keske1, J.E. Sharman1
1Menzies Research Institute Tasmania, University of Tasmania, Hobart, Australia
2School of Human Life Sciences, University of Tasmania, Launceston, Australia
Available Online 11 November 2013.
DOI
10.1016/j.artres.2013.10.159How to use a DOI?
Abstract

Objectives: The reference standard for non-invasive central blood pressure (BP) measurement is radial tonometry calibrated using brachial BP. Brachial-to-radial-systolic-BP-amplification (Bra-Rad-SBPAmp) may introduce error into central BP measurement but the magnitude of Bra-Rad-SBPAmp in healthy people is uncertain. This study aimed to determine the magnitude of Bra-Rad-SBPAmp as well as effects of ageing.

Methods: Forty healthy younger (28±5 years; 50% male) and 20 older (60±8 years; 50% male) participants underwent brachial and radial artery ultrasound measurement to identify SBP (1st Korotkoff sound) from the 1st Doppler flow inflection point during BP cuff deflation. Regional and local haemodynamics were recorded by ultrasound and tonometry. Bra-Rad-SBPAmp was calculated by radial minus brachial SBP.

Results: Radial SBP was significantly higher than brachial SBP in both younger (118±12mmHg versus 110±10mmHg; p<0.001) and older (135±12mmHg versus 121±11mmHg; p<0.001) participants. However, the magnitude of Bra-Rad-SBPAmp was higher in older age (14±7mmHg versus 8±7mmHg; p=0.004), and this was independent of heart rate, mean arterial pressure and sex. A higher proportion of older participants had major (>15mmHg) Bra-Rad-SBPAmp (45% versus 12.5%; p=0.028). Recalibration of radial waveforms using radial versus brachial SBP resulted in higher central SBP in both younger (p<0.001) and older (p<0.001) age groups (p<0.001 between groups). Brachial artery stiffness was related to Bra-Rad-SBPAmp in females only.

Conclusions: Major Bra-Rad-SBPAmp occurs in healthy people and is significantly increased with age. These findings have implications for correct central BP estimation using radial tonometry and brachial BP calibration, whereby greater underestimation of central SBP is likely with advancing age.

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<Previous Article In Issue
Next Article In Issue>
Journal
Artery Research
Volume-Issue
7 - 3-4
Pages
146 - 146
Publication Date
2013/11/11
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2013.10.159How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - D.S. Picone
AU  - R.E.D. Climie
AU  - K.D.K. Ahuja
AU  - M.A. Keske
AU  - J.E. Sharman
PY  - 2013
DA  - 2013/11/11
TI  - P5.10 MAJOR BRACHIAL-TO-RADIAL-SYSTOLIC-BLOOD-PRESSURE-AMPLIFICATION OCCURS IN HEALTHY PEOPLE AND IS SIGNIFICANTLY INCREASED WITH AGE
JO  - Artery Research
SP  - 146
EP  - 146
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.159
DO  - 10.1016/j.artres.2013.10.159
ID  - Picone2013
ER  -