Artery Research

Volume 7, Issue 3-4, September 2013, Pages 142 - 142

P4.23 CORRECTION OF VITAMIN D DEFICIENCY BY CALCIFEDIOL IN HYPERTENSIVES WITH STAGE 3 CHRONIC KIDNEY DISEASE REDUCES PULSE WAVE VELOCITY BY LOWERING BLOOD PRESSURE

Authors
Rodilla Sala Enrique1, 2, Costa Muñoz José Antonio1, Porcar Paula1, Pascual Izuel José María1, 3, Malek Marín Tamara1
1Unidad HTA y Riesgo Vascular, Servicio Medicina Interna, Hospital de Sagunto, Sagunto, Spain
2Facultad de Ciencias de la Salud, Universidad Cardenal Herrera, Castellón, Castellón, Spain
3Facultad de Medicina, Universidad de Valencia, Valencia, Spain
Available Online 11 November 2013.
DOI
10.1016/j.artres.2013.10.141How to use a DOI?
Abstract

Objectives: To measure the extent of correction of vitamin D deficiency and hyperparathyroidism after treatment with calcifediol as well as their relationship to blood pressure and arterial stiffness in hypertensive patients with stage 3 chronic kidney disease (CKD).

Methods: Longitudinal study that included 74 treated hypertensives (46 women, 62,2%) with stage 3 CKD (eGFR 47,7 ml/min, SD±10) without previous vitamin D supplementation treatment. Calcifediol 266 μg/2 weeks and calcium 600 mg/d were given if baseline-vitamin D < 30 ng/ml and < 9,5 mmol/l, respectively. A second visit took place after 4 months.

Results: The mean age was 72,9 years (SD±10). The prevalence of vitamin D deficiency decreased from initially 96% to 23% (mean baseline: 18, mean final: 42 ng/ml), and of secondary hyperparathytoidism from 62% to 37% (mean at baseline: 87, mean final: 63 pg/ml). There were no significant changes in eGFR, calcium or phosphor or number of antihypertensive drugs, but pulse wave velocity (measured with MOBILOGRAPH®) and BP decreased significantly form initially 133/76 to 123/72 (p<0.001) mmHg and from 10,8 to 10,5 m/sec (p<0.005), respectively. In bivariate analysis the difference between baseline and final vitamin D and PTH correlated significantly. The only variable significantly related to the change in PWV was the difference in peripheral SBP. Only one case of asymptomatic hypercalcemia was observed.

Conclusions: In hypertensive patients with stage 3 CKD, correction of vitamin D deficiency by oral caldifediol leads to a substantial reduction of incipient hyperparathyroidism and a significant decrease of arterial stiffness.

Open Access
This is an open access article distributed under the CC BY-NC license.

Journal
Artery Research
Volume-Issue
7 - 3-4
Pages
142 - 142
Publication Date
2013/11/11
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2013.10.141How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Rodilla Sala Enrique
AU  - Costa Muñoz José Antonio
AU  - Porcar Paula
AU  - Pascual Izuel José María
AU  - Malek Marín Tamara
PY  - 2013
DA  - 2013/11/11
TI  - P4.23 CORRECTION OF VITAMIN D DEFICIENCY BY CALCIFEDIOL IN HYPERTENSIVES WITH STAGE 3 CHRONIC KIDNEY DISEASE REDUCES PULSE WAVE VELOCITY BY LOWERING BLOOD PRESSURE
JO  - Artery Research
SP  - 142
EP  - 142
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.141
DO  - 10.1016/j.artres.2013.10.141
ID  - SalaEnrique2013
ER  -