P4.11 SERUM UREA IS A NEW BIOMARKER OF CELLULAR AND VASCULAR AGING

DOI

10.1016/j.artres.2013.10.129How to use a DOI?

Abstract

Objective: Large arteries stiffness is a feature of arterial aging and a predictor of cardiovascular diseases. The length of telomere (TL) in leukocytes is widely considered as a biomarker for cellular aging, cardiovascular aging and cardiovascular diseases. High concentrations of urea is known to increase oxidative stress. The aim of our study was to determine whether the indicators of renal function are associated with TL and arterial stiffness, evaluated by measuring aortic pulse wave velocity (PWV).

Methods: The study group included 150 subjects free of known cardiovascular diseases, kidney diseases, anti-diabetes, antihypertensive and lipid lowering medications. PWV was measured with the help of SphygmoCor (AtCor Medical). Telomere length has been determined by quantitative polymerase chain reaction. Renal function was assessed by creatinine clearance calculated with the MDRD formula . Microalbuminuria (MAU) and urea levels were determined using routine laboratory methods.

Results: Pearson’s correlations are demonstrated in the table 1 and table 2.

	TL
Age	r= −0,2860
	p= 0,0003
Creatinine clearance (ml/min)	r= −0,4267
	p= 0,0167
MAU (mg/l)	r= −0,2718
	p= 0,0175
Urea (mmol/l)	r= −0,2521
	p= 0,0098

	PWV
Age	r= 0,5223
	p= 0,0001
TL	r= −0,2657
	p= 0,0096
Creatinine clearance (ml/min)	r= 0,1964
	p= 0,2814
MAU (mg/l)	r= 0,0186
	p= 0,8544
Urea (mmol/l)	r= 0,1784
	p= 0,0384

In conclusion, even physiological concentrations of plasma urea contribute to cellular and vascular aging. TL may play a role in kidney function. The relationship between TL and kidney repair and regeneration needs increasing studies.

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TY  - JOUR
AU  - V. Pykhtina
AU  - I. Strazhesko
AU  - D. Akasheva
AU  - A. Kruglikova
AU  - E. Plokhova
AU  - O. Isaykina
AU  - O. Tkacheva
AU  - S. Boytsov
PY  - 2013
DA  - 2013/11/11
TI  - P4.11 SERUM UREA IS A NEW BIOMARKER OF CELLULAR AND VASCULAR AGING
JO  - Artery Research
SP  - 138
EP  - 138
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.129
DO  - 10.1016/j.artres.2013.10.129
ID  - Pykhtina2013
ER  -