P4.13 VITAMIN D SUPPLEMENTATION IMPROVES ENDOTHELIAL FUNCTION IN TYPE 2 DIABETES – A RANDOMIZED CONTROLLED TRIAL

DOI

10.1016/j.artres.2013.10.131How to use a DOI?

Abstract

Background: Cardiovascular disease is prevalent in type 2 diabetes, and both endothelial dysfunction and arterial stiffness may contribute in the pathogenesis. Low levels of vitamin D are associated with both type 2 diabetes and cardiovascular disease.

Aim: To evaluate the effect of vitamin D supplementation on endothelial function and arterial stiffness in subjects with type 2 diabetes and hypovitaminosis D.

Methods: Sixty-two subjects with type 2 diabetes and serum 25-hydroxy-vitamin D [25(OH)D] <50 nmol/L were included in this randomized controlled trial (NCT 00992797). Thirty-three patients received vitamin D (400 000 IU cholecalciferol) at baseline, whereas 29 patients received placebo. Endothelial function and arterial stiffness were measured at baseline and after six months. Endothelial function was assessed as the reactive hyperaemia index (RHI) using endothelial pulse amplitude testing (Endo-PAT). Arterial stiffness was estimated as carotid-femoral pulse wave velocity (cfPWV) and augmentation index (AIx) with the SphygmoCor device. Serum 25(OH)D was measured using the DiaSorin-RIA.

Results: Mean (SD) age in the treatment and placebo group were 57.5 (9.4) and 57.8 (10.0) years, 51.5 % (n=17) and 44.8 (n=13) were females, and diabetes duration was 11.4 (6.5) and 7.5 (5.7) years. Vitamin D supplementation significantly improved RHI and increased the 25(OH)D levels, but did not change cfPWV and AIx (Table 1). In multivariable regression analysis, change in RHI was significantly associated with change in 25(OH)D levels (β [CI] = 0.009 [0.001–0.017], P=0.03).

Conclusion: Vitamin D supplementation improved endothelial function but not arterial stiffness in subjects with type 2 diabetes.

	Baseline			Change
	Treatment (n=33)	Control (n=29)	P	Treatment (n=33)	Control (n=29)	P
RHI	1.7 (0.4)	1.7 (0.5)	0.74	0.21 (0.49)	−0.03 (0.37)	0.04
cfPWV, m/s	10.18 (1.85)	9.84 (2.33)	0.54	−0.21 (0.92)	−0.10 (0.64)	0.56
AIx, %	20.0 (8.7)	20.0 (10.1)	0.98	0.8 (5.0)	3.5 (8.4)	0.54
25(OH)D, nmol/L	38.5 (9.1)	38.1 (8.5)	0.74	15.0 (11.0)	0.7 (16.0)	<0.001

Table 1

Baseline values and change in endothelial function, arterial stiffness and vitamin D from baseline to 6 months. Values are given as mean (SD). P represents the significance of between-group-comparisons for baseline values and changes after 6 months respectively.

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TY  - JOUR
AU  - K. Angel
AU  - H.L. Gulseth
AU  - C. Wium
AU  - E.F. Eriksen
AU  - D. Atar
AU  - K. Birkeland
PY  - 2013
DA  - 2013/11/11
TI  - P4.13 VITAMIN D SUPPLEMENTATION IMPROVES ENDOTHELIAL FUNCTION IN TYPE 2 DIABETES – A RANDOMIZED CONTROLLED TRIAL
JO  - Artery Research
SP  - 139
EP  - 139
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.131
DO  - 10.1016/j.artres.2013.10.131
ID  - Angel2013
ER  -