P3.32 THE NUMBER OF METABOLIC SYNDROME RISK FACTORS CORRELATES WITH AORTIC STIFFNESS

DOI

10.1016/j.artres.2013.10.119How to use a DOI?

Abstract

Objectives: Metabolic syndrome (MS) is a cluster of ≥3 risk factors (RF). The presence of subclinical organ damage increases the risk of cardiovascular disease in patients with MS. Arterial stiffness and wave reflections are independent predictors of cardiovascular disease. The aim of our study was to compare pulse wave velocity (PWV) and parameters of wave reflections in subjects with different number of MS risk factors (definition of MS according to Czech guidelines: arterial hypertension or antihypertensive drug treatment, waist circumference, serum triglycerides or lipid-lowering drug treatment, HDL cholesterol, type 2 diabetes mellitus or impaired glucose tolerance).

Methods: We examined 936 respondents from the Czech general population (post-MONICA study). We measured aortic PWV, augmentation index (AIx) and central augmentation pressure (cAP) using SphygmoCor device. We divided subjects into 5 groups according to number of RF (0,1,2,3, ≥4). We used multivariate linear regression analysis to assess association between the number of RF and PWV, AIx and cAP after adjustment for age, gender, heart rate and MAP.

Results: 334 respondents (35.7 %) had MS. Subjects with MS were older (60.4±9.8 years vs. 51.0±13.6 years, p<0.0001) and had higher PWV than subjects without MS (9.0±2.3 m/s vs. 7.3±2.1 m/s, p<0.0001). After adjustment for covariates, the PWV (p_{for trend} <0.0001), and cAP (p=0.025) were higher with increasing number of RF, while AIx was lower (p=0.020).

Conclusions: With growing number of metabolic syndrome risk factors, the aortic PWV and central augmentation pressure increase, while opposite is true for central augmentation index.

Open Access

This is an open access article distributed under the CC BY-NC license.

TY  - JOUR
AU  - Vágovičová Petra
AU  - Mlíková Seidlerová Jitka
AU  - Filipovský Jan
AU  - Mayer Otto
AU  - Wohlfahrt Peter
AU  - Cífková Renata
PY  - 2013
DA  - 2013/11/11
TI  - P3.32 THE NUMBER OF METABOLIC SYNDROME RISK FACTORS CORRELATES WITH AORTIC STIFFNESS
JO  - Artery Research
SP  - 135
EP  - 135
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.119
DO  - 10.1016/j.artres.2013.10.119
ID  - Petra2013
ER  -