P4.14 RENAL DENERVATION IMPROVES CENTRAL HEMODYNAMICS AND PULSE PRESSURE AMPLIFICATION IN PATIENTS WITH TREATMENT RESISTANT HYPERTENSION

C. Ott; A. Schmid; T. Ditting; R. Veelken; M. Uder; R.E. Schmieder

doi:10.1016/j.artres.2013.10.132

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Volume 7, Issue 3-4, September 2013, Pages 139 - 139

P4.14 RENAL DENERVATION IMPROVES CENTRAL HEMODYNAMICS AND PULSE PRESSURE AMPLIFICATION IN PATIENTS WITH TREATMENT RESISTANT HYPERTENSION

Authors

C. Ott¹, A. Schmid², T. Ditting¹, R. Veelken¹, M. Uder², R.E. Schmieder¹

¹Department of Nephrology and Hypertension, University of Erlangen-Nuremberg, Erlangen, Germany

²Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany

Available Online 11 November 2013.

DOI: 10.1016/j.artres.2013.10.132 How to use a DOI?
Abstract: Background: Renal denervation (RDN) was shown to be effective in reducing peripheral BP in treatment resistant hypertension. Accumulating data suggest that central pressures may be a better predictor of cardiovascular events and outcomes than the corresponding peripheral pressure. PP amplification is among others inversely related to stiffer arteries and peripheral arterial resistance.

Methods: 57 patients with treatment resistant hypertension (office BP ≥140/90 mmHg, while on at least 3 antihypertensive agents, and diagnosis confirmed by 24-h ABPM ≥130/80 mmHg) underwent catheter-based RDN using the Symplicity Flex^TM catheter (Medtronic Inc., Palo Alto, CA). In addition, in our lab pulse wave analysis was assessed with the SphygmoCor^TM device (AtCor Medical, Australia) before and after 6 months of RDN. PP amplification is determined as ratio of peripheral PP to central PP.

Results: Patients (59±12 years) were treated with 6.0±1.3 antihypertensive drugs on average. Peripheral as well as central systolic and diastolic BP were reduced (all p<0.01) 6 months after RDN. In accordance, peripheral PP (77.5±22 versus 71.5±23 mmHg, p=0.008) and central PP (63.2±21 versus 56.7±22 mmHg, p=0.001) were reduced 6 months after RDN. Consistently, there was a significant improvement in PP amplification (1.25±0.2 versus 1.30±0.2, p=0.012). Also central augmentation pressure (20±12 versus 16±13 mmHg, p<0.001) and cAIx@75 (24±10 versus 21±11 %, p=0.005) decreased 6 months after RDN. There was no change on heart rate (63±11 versus 64±10 bpm, p=0.499).

Conclusion: Our data suggest that RDN might exert beneficial effects indicated by an improvement of central PP beyond peripheral PP, and hence PP amplification.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 7 - 3-4
Pages: 139 - 139
Publication Date: 2013/11/11
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2013.10.132 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - C. Ott
AU  - A. Schmid
AU  - T. Ditting
AU  - R. Veelken
AU  - M. Uder
AU  - R.E. Schmieder
PY  - 2013
DA  - 2013/11/11
TI  - P4.14 RENAL DENERVATION IMPROVES CENTRAL HEMODYNAMICS AND PULSE PRESSURE AMPLIFICATION IN PATIENTS WITH TREATMENT RESISTANT HYPERTENSION
JO  - Artery Research
SP  - 139
EP  - 139
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.132
DO  - 10.1016/j.artres.2013.10.132
ID  - Ott2013
ER  -

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