Artery Research

Volume 7, Issue 3-4, September 2013, Pages 131 - 131

P3.17 EFFECT OF HYPERTENSION ON ARTERIAL STIFFNESS IN GHANAIAN SUBJECTS WITH TYPE 2 DIABETES

Authors
K. Yeboah1, D.A. Antwi1, B. Gyan1, V. Govoni2, J.K. Cruickshank2, A.G.B. Amoah1, 3
1University of Ghana, Accra, Ghana
2King’s College, London, United Kingdom
3National Diabetes management Centre, Korle Bu Teaching Hospital, Accra, Ghana
Available Online 11 November 2013.
DOI
10.1016/j.artres.2013.10.104How to use a DOI?
Abstract

Background: Hypertension exacerbates cardiovascular disease in type 2 diabetes (T2DM) but the ACCORD trial suggested limited impact on CVS events by hypertensive treatment. Our hypothesis is that arterial stiffness, measured as aortic pulse wave velocity (PWV) may underlie these events. Few data exist on arterial stiffness in hypertensive diabetes patients in sub-Saharan Africa, where the two conditions are becoming epidemic. We compared indices of arterial stiffness in T2DM subjects with (T2DM+HT), without (T2DM-HT) hypertension and normotensive non-diabetes (NDM).

Methods: Forty eight T2DM+HT, 45 T2DM-HT and 34 NDM volunteers (as screened by OGTT), between the ages of 40–70 years, were randomly recruited. Weight, height and waist circumference (WC) were measured. Indices of arterial stiffness, pulse wave velocity (PWV), aortic systolic blood pressure (aSBP), and aortic augmentation index(aAlx) were measured with Arteriograph (Tensiomed, Hungary) and Cardio-Ankle Vascular Index (CAVI) with Vasera 1500 (Fukuda-Denshi, Tokyo, Japan) in supine subjects after 10 minutes rest in a temperature controlled room.

Results: In a univariate analysis, after adjusting for gender, age in decade, BMI and waist circumference, mean values of CAVI (8.43±1.31 vs. 7.4±1.05 vs. 7.00±0.87; p<0.001), PWV (9.16±1.04 vs. 7.98±1.28 vs. 7.64±1.42; p<0.001), aSBP (153.94±25.62 vs. 115.72±11.11 vs. 117.06±11.11; p<0.001) and aAIx (28.53±12.43 vs. 19.18±11.47 vs. 26.21±14.08; p=0.026) were higher in T2DM+HT than T2DM-HT, which was also higher than NDM. Contrast analysis showed no significant difference between aSBP between T2DM-HT and NDM.

Conclusion: Hypertension increases arterial stiffness in T2DM subjects in Ghana.

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Journal
Artery Research
Volume-Issue
7 - 3-4
Pages
131 - 131
Publication Date
2013/11/11
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2013.10.104How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - K. Yeboah
AU  - D.A. Antwi
AU  - B. Gyan
AU  - V. Govoni
AU  - J.K. Cruickshank
AU  - A.G.B. Amoah
PY  - 2013
DA  - 2013/11/11
TI  - P3.17 EFFECT OF HYPERTENSION ON ARTERIAL STIFFNESS IN GHANAIAN SUBJECTS WITH TYPE 2 DIABETES
JO  - Artery Research
SP  - 131
EP  - 131
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.104
DO  - 10.1016/j.artres.2013.10.104
ID  - Yeboah2013
ER  -