Artery Research

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Volume 7, Issue 3-4, September 2013, Pages 130 - 130

P3.15 ARTERIAL STIFFNESS IN NON-HYPERTENSIVE GHANAIAN SUBJECTS WITH TYPE 2 DIABETES

Authors
K. Yeboah1, A.G.B. Amoah2, 3, D.A. Antwi1, B. Gyan4, V. Govoni5, J.K. Cruickshank5
1Department of Physiology, University of Ghana Medical School, Accra, Ghana
2Department of Medicine and Therapeutics, University of Ghana Medical School, Accra, Ghana
3National Diabetes Management and Research Centre, Korle Bu Teaching Hospital, Korle Bu, Ghana
4Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana
5King’s College London, London, United Kingdom
Available Online 11 November 2013.
DOI
10.1016/j.artres.2013.10.102How to use a DOI?
Abstract

Background: Limited data exists on arterial stiffness in sub-Sahara Africa where diabetes and cardiovascular diseases are increasing rapidly. We aimed to compare the indices of arterial stiffness among type 2 diabetes (T2DM) and non-diabetes subjects (NDM), without hypertension, in Ghana.

Method: Thirty eight T2DM patients and 34 NDM volunteers (as screened by OGTT), between the ages of 40–70 years, were randomly recruited, with no history of antihypertensive medication and supine blood pressure (BP) < 140/90 mmHg. Weight, height and waist circumference (WC) were measured. Indices of arterial stiffness, pulse wave velocity (PWV), aortic systolic blood pressure (ASBP), and aortic augmentation index (AAlx) were measured with Arteriograph (Tensiomed, Hungary) . The Cardio-Ankle Vascular Index (CAVI) & derived PWV were measured with the 4-cuff Vasera 1500 (Fukuda-Denshi, Tokyo, Japan) supine after 10 minutes rest in a temperature-controlled room.

Results: There was no difference in the gender distribution (p=0.6), mean age (p=0.2), BMI (p=0.07) and WC (p=0.4) between T2DM and NDM subjects. Also, mean (±SD) brachial systolic (124.9±9.6 vs. 121.9±10.0, p=0.3) and diastolic (74.3±7.6 vs. 71.22±9.7, p=0.6) BP did not differ between T2DM and NDM, respectively. However, T2DM subjects had slightly higher PWV (8.2±1.1 vs 7.1±0.98, p=0.048), CAVI (7.76±1.12 vs. 6.73±0.66, p=0.042, but lower AAIx (19.3±10.4 vs. 27.7±15.1, p=0.02), respectively. There was no difference in ASBP between T2DM and NDM subjects (116.7±11.7 vs. 117.5±12, p=0.8).

Conclusion: In the Ghanaian setting, T2DM may have a greater impact on indices of arterial stiffness in the absence of overt arterial hypertension.

Open Access
This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
7 - 3-4
Pages
130 - 130
Publication Date
2013/11/11
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2013.10.102How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - K. Yeboah
AU  - A.G.B. Amoah
AU  - D.A. Antwi
AU  - B. Gyan
AU  - V. Govoni
AU  - J.K. Cruickshank
PY  - 2013
DA  - 2013/11/11
TI  - P3.15 ARTERIAL STIFFNESS IN NON-HYPERTENSIVE GHANAIAN SUBJECTS WITH TYPE 2 DIABETES
JO  - Artery Research
SP  - 130
EP  - 130
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.102
DO  - 10.1016/j.artres.2013.10.102
ID  - Yeboah2013
ER  -