Artery Research

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Volume 7, Issue 3-4, September 2013, Pages 130 - 130

P3.12 PULSE WAVE VELOCITY AND DIABETES DURATION IN TYPE 2 DIABETES MELLITUS

Authors
D. Agnoletti1, 2, S. Millasseau3, A. Salah-Mansour4, A.D. Protogerou5, Y. Zhang6, C. Borghi2, J. Blacher1, M. Safar1
1Paris Descartes University, APHP Hotel Dieu, Diagnosis and therapeutic center, Paris, France
2dpt of internal Medicine, University of Bologna, Bologna, Italy
3Pulse Wave Consulting, Saint Leu la Foret, France
4Dpt of Internal Medicine or Tizi Ouzou Hospital, Tizi Ouzou, Algeria
5Dpt of Internal Medicine, Medical School, University of Maastricht, Maastricht, Netherlands
6Dpt of Cardiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China
Available Online 11 November 2013.
DOI
10.1016/j.artres.2013.10.100How to use a DOI?
Abstract

Type 2 diabetes mellitus (T2DM) duration is related to early vascular aging and diabetic complications. Aortic stiffness is considered an integrated marker of the combined effect of cardiovascular risk factors, and could represent one of the links between diabetes and cardiovascular disease. To our knowledge, no study has been carried out to specially look at the relationship between aortic stiffness and T2DM duration. 618 patients (259 men) attending the Department of Internal Medicine of Tizi Ouzou Hospital (Algeria) underwent medical examination. Anthropometric, clinical and biological data were sampled; brachial blood pressure was measured, and aortic stiffness assessed from pulse wave velocity (PWV) was obtained. Diabetes duration collected from date of 1st diagnostic and analyzed by tertiles (<2 years; 2–9 years; >9 years). From lower to higher tertile of diabetes duration, age, brachial blood pressure and PWV increased, while diabetes control and renal function worsened (all p<0.01). After adjustment for age and blood pressure, microalbuminuria or insulin therapy, PWV was still higher in the higher duration tertile compare to the other 2. However the difference in PWV was negligeable after adjustment between the 2 lowest duration tertile. Diabetes duration is an important and independent determinant of PWV in type 2 diabetics. This is mainly true for higher durations, reflecting diabetes specific contributions to accelerated vascular stiffening. Furthermore, with aging, physiopathology of arterial stiffness involves other mechanisms that overwhelm diabetes duration.

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This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
7 - 3-4
Pages
130 - 130
Publication Date
2013/11/11
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2013.10.100How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - D. Agnoletti
AU  - S. Millasseau
AU  - A. Salah-Mansour
AU  - A.D. Protogerou
AU  - Y. Zhang
AU  - C. Borghi
AU  - J. Blacher
AU  - M. Safar
PY  - 2013
DA  - 2013/11/11
TI  - P3.12 PULSE WAVE VELOCITY AND DIABETES DURATION IN TYPE 2 DIABETES MELLITUS
JO  - Artery Research
SP  - 130
EP  - 130
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.100
DO  - 10.1016/j.artres.2013.10.100
ID  - Agnoletti2013
ER  -