Artery Research

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Volume 7, Issue 3-4, September 2013, Pages 134 - 134

P3.29 ASSESSMENT OF THE DETERMINANTS OF LOCAL CAROTID STIFFNESS IN A GENERAL POPULATION IN NORTHERN ITALY

Authors
C. Aggiusti, A. Paini, M. Salvetti, F. Bertacchini, D. Stassaldi, C. Agabiti Rosei, G. Maruelli, G. Rubagotti, E. Agabiti Rosei, M.L. Muiesan
University of Brescia, Brescia, Italy
Available Online 11 November 2013.
DOI
10.1016/j.artres.2013.10.116How to use a DOI?
Abstract

Background: The determinants of aortic stiffness have been elucidated in several studies, while few data are available for carotid stiffness. Aim of the study was to identify the main determinants of carotid arterial stiffness parameters in a general population in Northern-Italy(Vobarno Study).

Methods:183subjects(61% female, mean age 55± 4,53% hypertensives,59% treated) underwent laboratory examinations and both clinic and 24 hours BP measurement (Spacelabs 90207). A non-invasive echotracking system was used to measure intima-media thickness, diameter, distension, distensibility (Dist), distensibility coefficient (CDist), compliance coefficient (CC) and elastic modulus (Einc) on 4-cm long common carotid artery segment.

Results: correlation coefficient of Dist, CDist and Einc are shown in Table 1.

Dist CDist Einc
R p r p r p
Age (years) −0.240* 0.001 −0.241* 0.001 0.210* 0.005
BMI (Kg/m2) −0.192* 0.01 −0.192* 0.010 0.169* 0.024
Clinic SBP (mmHg) −0.501* 0.001 −0.477* 0.000 0.511* 0.000
Clinic DBP (mmHg) −0.181* 0.015 −0.184* 0.014 0.262* 0.000
Clinic MBP (mmHg) −0.374* 0.001 −0.362* 0.000 0.422* 0.000
24 hours SBP (mmHg) −0.207* 0.006 −0.198* 0.009 0.222* 0.003
24 hours DBP (mmHg) −0.183* 0.016 −0.191* 0.012 0.207* 0.006
24 hours MBP(mmHg) −0.13 0.094 −0.125 0.099 0.166* 0.029

At multivariate analysis the independent predictor of Dist,CDist and Einc were age (β=−0.22, β=−0.22 and β=0.18, respectively, all p<0.01), BMI (β=−0.18, β=−0.18 and β=0.14, respectively, all p<0.05),MBP (β=−0.34, β=−0.33 and β=0.40, respectively, all p<0.001)and female gender(β=0.19,β=0.18 and β=−0.15,respectively,all p<0.05).When carotid arterial stiffness parameters were compared in males and females,a significantly lower values of Dist and CC were observed in females (365±97 vs 427±124 μm,p<0.001 and 0.63±0.24 vs 0.83±0.29 mm2/kPa−1,p<0.001, respectively).After adjusting for possible confounders in a multivariate model distension(345 vs 456 μm, p<0.001),CDist (23.4 vs 30.3 kPa−1*10−3, p<0.001) and CC (0.61 vs 0.87 mm2/kPa−1, p<0.001)were significantly lower in females while Einc was significantly higher in females(0.45 vs 0.34 kPa*103,p=0.007).Conclusion: in a general population sample age, female gender, BMI and clinic and 24 hours BP values are associated to an increase local carotid stiffness.

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Journal
Artery Research
Volume-Issue
7 - 3-4
Pages
134 - 134
Publication Date
2013/11/11
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2013.10.116How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - C. Aggiusti
AU  - A. Paini
AU  - M. Salvetti
AU  - F. Bertacchini
AU  - D. Stassaldi
AU  - C. Agabiti Rosei
AU  - G. Maruelli
AU  - G. Rubagotti
AU  - E. Agabiti Rosei
AU  - M.L. Muiesan
PY  - 2013
DA  - 2013/11/11
TI  - P3.29 ASSESSMENT OF THE DETERMINANTS OF LOCAL CAROTID STIFFNESS IN A GENERAL POPULATION IN NORTHERN ITALY
JO  - Artery Research
SP  - 134
EP  - 134
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.116
DO  - 10.1016/j.artres.2013.10.116
ID  - Aggiusti2013
ER  -