Artery Research

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Volume 7, Issue 3-4, September 2013, Pages 127 - 127

P3.02 MORNING BLOOD PRESSURE SURGE, BLOOD PRESSURE VARIABILITY AND AORTIC STIFFNESS IN ESSENTIAL HYPERTENSION

Authors
G. Pucci1, F. Battista1, G. Bilo2, G. Parati2, 3, G. Schillaci1
1Department of Medicine, University of Perugia, Unit of Internal Medicine, Terni, Italy
2Department of Cardiology, San Luca Hospital, Istituto Auxologico Italiano, Milano, Italy
3Department of Clinical Medicine and Prevention, University of Milano-Bicocca, Milano, Italy
Available Online 11 November 2013.
DOI
10.1016/j.artres.2013.10.090How to use a DOI?
Abstract

Morning blood pressure surge is associated with increased cardiovascular risk, possibly due to its ability to reflect short-term BP variability and/or its link with arterial stiffness. The link between morning BP surge and vascular stiffness is not defined.

689 untreated hypertensives (48±10 years, BP 149/92±17/10 mmHg) underwent c-f PWV and 24-h ambulatory BP measurement. Morning surge was calculated as: sleep-trough surge (STS, 2-hour average SBP after wake-up minus average of 3 SBP centered on the lowest nighttime reading), pre-awakening surge (PAS, 2-hour average SBP after wake-up minus 2-hour average SBP before wake-up), and rising BP surge (RBS, SBP on rising minus the lowest SBP in the 30’before). Average real variability (ARV, 24h average of the absolute differences between consecutive SBP), was considered a measure of short-term SBP variability.

STS and RBS were directly correlated to cfPWV (r=0.17 and r=0.12,p<0.01) and ARV (r=0.28 and r=0.23,p<0.001), while PAS had no such relationships. Patients in the top quartile of STS (>39 mmHg) had higher age- and 24-h mean BP-adjusted cfPWV (9.73±2 vs 9.29±2 m/s, p=0.004), while no difference was found for the top quartile of PAS or RBS. In a multivariate regression, high STS values predicted a high cfPWV (β=0.08,p=0.038), independently of age, sex, 24-h mean BP and nocturnal BP reduction. After adding ARV (β=0.17,p<0.001) to the model, the relationship between STS and cfPWV was no longer significant (β=0.05,p=0.17).

Morning SBP surge, calculated as STS, has a positive relation with aortic stiffness in hypertension, which is no longer significant after adjusting for 24-h short-term BP variability.

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<Previous Article In Issue
Next Article In Issue>
Journal
Artery Research
Volume-Issue
7 - 3-4
Pages
127 - 127
Publication Date
2013/11/11
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2013.10.090How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - G. Pucci
AU  - F. Battista
AU  - G. Bilo
AU  - G. Parati
AU  - G. Schillaci
PY  - 2013
DA  - 2013/11/11
TI  - P3.02 MORNING BLOOD PRESSURE SURGE, BLOOD PRESSURE VARIABILITY AND AORTIC STIFFNESS IN ESSENTIAL HYPERTENSION
JO  - Artery Research
SP  - 127
EP  - 127
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.090
DO  - 10.1016/j.artres.2013.10.090
ID  - Pucci2013
ER  -