P3.05 UNFAVORABLE EFFECT OF ANDROGEN DEFICIENCY ON AORTIC STIFFNESS IN HYPERTENSIVE MALES AT LOW AND MODERATE CARDIOVASCULAR RISK

DOI

10.1016/j.artres.2013.10.093How to use a DOI?

Abstract

Objectives: Increased carotid-femoral Pulse Wave Velocity (PWVc-f) identify hypertensive patients at high CV risk, independently of systematic coronary risk evaluation (SCORE). Testosterone is associated with aortic stiffness, however whether this association is different in hypertensive patients with low or intermediate SCORE compared to high SCORE subjects is unknown.

Methods: Total testosterone (TT) and PWVc-f were measured in 311 non-diabetic hypertensive men with no evidence of clinical atherosclerosis. Hypogonadism (HypG) was defined when TT levels were below 3.4 ng/ml.

Results: The prevalence of HypG in hypertensive patients with low, moderate and high SCORE was 12.5, 15.2 and 28.2%, respectively. PWVc-f was significantly associated with TT in low (r=−0.289, P<0.001) and moderate SCORE (r=−0.274, P<0.001) patients but not in patients with high SCORE (r=−0.092, P=0.33). Subjects were then categorized by SCORE and further subdivided according to presence/absence of HypG. PWVc-f values of each SCORE/testosterone category are shown in figure. In low and moderate SCORE categories, patients with HypG had higher PWVc-f (by 0.92 m/s, P<0.01 and 0.55 m/s, P<0.05, respectively) compared to subjects with TT above the cut off level for biochemical definition of HypG. On the contrary, in high SCORE category, PWVc-f between patients with HypG and men with normal levels did not differ. It can be noted that low and moderate SCORE hypertensive patients with HypG had already elevated PWVc-f as compared to high SCORE men with normal TT.

Conclusions: The effect of low testosterone concentration on aortic stiffness is emphasized in hypertensive patients with low and moderate SCORE.

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TY  - JOUR
AU  - C. Vlachopoulos
AU  - N. Ioakeimidis
AU  - A. Aggelis
AU  - P. Xaplanteris
AU  - D. Terentes-Printzios
AU  - M. Abdelrasoul
AU  - P. Pietri
AU  - C. Stefanadis
PY  - 2013
DA  - 2013/11/11
TI  - P3.05 UNFAVORABLE EFFECT OF ANDROGEN DEFICIENCY ON AORTIC STIFFNESS IN HYPERTENSIVE MALES AT LOW AND MODERATE CARDIOVASCULAR RISK
JO  - Artery Research
SP  - 128
EP  - 128
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.093
DO  - 10.1016/j.artres.2013.10.093
ID  - Vlachopoulos2013
ER  -