P3.09 STIFFER ARTERIES IN “HEALTHY” SUBJECTS WITH COMPONENTS OF THE METABOLIC SYNDROME

DOI

10.1016/j.artres.2013.10.097How to use a DOI?

Abstract

Objectives: To compare indices of vascular stiffness and markers of adiposity and inflammation in “healthy” subjects with/without components of the metabolic syndrome (met-x).

Methods: Subjects satisfying ≥1 (≥1 Met-X;) and no criteria (0 Met-X) were recruited (IDF 2006). All were lifelong non-smokers, normotensive, normolipidaemic and normoglycaemic. Augmentation index (AIx) and pulse wave velocity (PWV) were measured using applanation tonometry (Sphygmacor & Vicorder). Fasting leptin, adiponectin, IL-6, TNFα & MCP-1 were measured. Unpaired students t-test and Fischer’s exact test was used to detect differences.

Results: Anthropometric, metabolic and haemodynamic indices of the met-x syndrome were significantly higher in the ≥1 Met-X group (p<0.0001). AIx and PWV were higher in the ≥1 Met-X group. The adipose related hormones, leptin and adiponectin were higher and lower, respectively, in the ≥1 Met-X group but the pro-inflammatory markers, IL-6, TNFα & MCP-1 were not different (Table 1).

	0 Met-X criteria	≥1 Met-X criteria	P
n	91	106
Age (years)	37±10	40±8 years	0.06
Body fat (%)	22.64±6.74	30.44±7.71	<0.0001
AIx (%)	12.83±13.60	19.28±13.34	<0.001
PWV (m.s−1)	6.82±0.85	7.14±1.20	<0.05
Leptin (pg.mL−1.10−2)	100.39±73.44	168.93±123.94	<0.001
Adiponectin (pg.mL−1.10−2)	77.54±41.10	53.91±31.98	<0.001
IL-6 (pg.ml−1)	1.59±0.96	2.08±3.01	0.27
TNFα (pg.ml−1)	2.98±1.10	3.29±1.50	0.21
MCP-1 (pg.ml−1)	214.26±96.85	204.51±80.15	0.55

Table 1

Body fat composition, arterial stiffness and humoral adipose/pro-inflammatory markers in subjects with/without early signs of met-x. Results are mean±SD.

Conclusion: Subjects with early met-x have stiffer arteries than those with normal metabolic function. These results suggest that premature arterial stiffening may be mediated via hormonal rather than inflammatory mechanisms.

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TY  - JOUR
AU  - O. Mac Ananey
AU  - B. Mc Loughlin
AU  - I. Abuzaid
AU  - A. Leonard
AU  - P. Gaffney
AU  - G. Boran
AU  - V. Maher
PY  - 2013
DA  - 2013/11/11
TI  - P3.09 STIFFER ARTERIES IN “HEALTHY” SUBJECTS WITH COMPONENTS OF THE METABOLIC SYNDROME
JO  - Artery Research
SP  - 129
EP  - 129
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.097
DO  - 10.1016/j.artres.2013.10.097
ID  - MacAnaney2013
ER  -