Artery Research

Volume 7, Issue 3-4, September 2013, Pages 119 - 119

P2.01 HIGH RESOLUTION IMAGING OF SMALL ARTERIES IN THE HUMAN RETINA DURING HYPERTENSIVE RETINOPATHY

Authors
M. Paques2, E. Koch2, X. Girerd1, F. Rossant3, D. Rosenbaum1, J. Benesty2, J. Sahel2, P. Chaumet-Riffaud2
1Cardiovascular Prevention Unit, Pitié Salpêtrière Hospital, Paris, France
2Clinical Investigation Center 503, Paris, France
3SEP, Paris, France
Available Online 11 November 2013.
DOI
10.1016/j.artres.2013.10.063How to use a DOI?
Abstract

Objective: Morphological changes affecting small arteries are recognized surrogates of end-organ damage due to aging and/or hypertension. However, the corresponding structural modifications of the wall of microvessels are poorly known. Here, using adaptive optics (AO) infrared imaging, we analyzed the vascular microstructures in subjects with various degree of hypertensive retinopathy.

Methods: The wall-to-lumen ratio (WLR) of the superotemporal artery was measured in 40 normotensive or treatment-naïve hypertensive subjects using a semi-automated procedure. Areas of focal vascular damage were also analyzed.

Results: Intra- and interobserver reproducibility was high (ICC over 0.8 for all parameters measured). In treatment-naïve subjects, the WLR of the superotemporal artery (mean ± SD 0.31 ± 0.08) was independently correlated with diastolic blood pressure (p<0.01), and lumen diameter (p<0.01). Neither focal arteriolar narrowing (FANs; (n=10) or arteriovenous nicking (AVNs; n=12) showed parietal thickening. Instead, at sites of FANs, a reduction of the outer diameter was consistently found, while at sites of AVNs venous narrowing and retinal opacification were observed distal to the arteriovenous interface. In addition, in four cases of AVNs the absence of arteriovenous contact could be unequivocally demonstrated.

Interpretation: AO imaging allows a reproducible analysis of the lumen diameter and parietal thickness of retinal vessels. Parietal thickness of retinal arterioles was correlated to blood pressure, but not focal lesions which appeared to involve either focal vasoconstriction and/or periarteriolar changes. AO imaging may thus contribute to a better understanding of end-organ damage linked to microvasculopathy.

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Journal
Artery Research
Volume-Issue
7 - 3-4
Pages
119 - 119
Publication Date
2013/11/11
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2013.10.063How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - M. Paques
AU  - E. Koch
AU  - X. Girerd
AU  - F. Rossant
AU  - D. Rosenbaum
AU  - J. Benesty
AU  - J. Sahel
AU  - P. Chaumet-Riffaud
PY  - 2013
DA  - 2013/11/11
TI  - P2.01 HIGH RESOLUTION IMAGING OF SMALL ARTERIES IN THE HUMAN RETINA DURING HYPERTENSIVE RETINOPATHY
JO  - Artery Research
SP  - 119
EP  - 119
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.063
DO  - 10.1016/j.artres.2013.10.063
ID  - Paques2013
ER  -