Artery Research

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Volume 7, Issue 3-4, September 2013, Pages 111 - 111

P1.03 LEFT VENTRICULAR REMODELING: IMPACT OF GLOBAL, REGIONAL AND LOCAL AORTIC STIFFNESS

Authors
T.Q.S. Quinaglia1, 2, M.Z.B. Bensalah2, 3, E.B. Bollache3, N.K. Kachenoura3, L.M. Macron3, P.B. Boutouyrie1, 2, S.L. Laurent1, 2, E.M. Mousseaux1, 2
1PARCC, INSERM UMR 970, Paris, France
2Université Paris Descartes and Assistance Publique Hôpitaux de Paris (AP-HP), Hôpital Européen Georges Pompidou (HEGP), Paris, France
3INSERM U678, Laboratoire d’imagerie fonctionnelle (LIF), UPMC (Univ Paris 6), Paris, France, Paris, France
Available Online 11 November 2013.
DOI
10.1016/j.artres.2013.10.034How to use a DOI?
Abstract

Objectives: Left ventricular (LV) concentric remodeling predicts all cause and CV mortality in various subsets of patients. Large arteries stiffness determines cardiac afterload and therefore LV remodeling. Since elastic properties of the arterial wall vary along the aortic pathway, we hypothesized that stiffness of consecutive aortic segments could have different impact on LV remodeling.

Methods: Global aortic stiffness was obtained from carotid-femoral pulse wave velocity (cfPWV, m/s) aplanation tonometry (Pulse Pen), and regional stiffness from aortic arch PWV phase contrast MRI. Local stiffness (m/s) was calculated in ascending (aaPWV) and descending aorta (daPWV) using cine MRI acquisition and surface change estimation (Bramwell-Hill equation). LV remodeling, MRI estimated, was expressed as LV mass over end diastolic volume ratio (M/V).

Results: We evaluated 146 patients (41±15 years old; 43.8% women) free of overt CV disease (hypertensives: 9.6%; smokers: 8.9%; diabetics: 0.6%; BMI: 23.8±3.5). In multivariate regression analysis cfPWV and aaPWV strongly correlated to M/V (partial R2=0.07, p=0.0011; and partial R2=0.10, p=0.0001, respectively), after adjustment for age, sex, BMI and brachial MBP. Challenged together, both cfPWV and aaPWV independently determined M/V, with 5% and 8% of explained variance, respectively. To a lower extent, daPWV (Partial R2= 0.04, p=0.0115) was also independently related to M/V. Arch PWV was not independently associated with M/V.

Conclusions: In this cross-sectional study, stiffness of diverse segments of the aorta had different influence on LV remodeling, except arch PWV. Stiffness of ascending aorta and the carotid-femoral pathway were complementary and also the strongest explanatory variables for LV remodeling.

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This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
7 - 3-4
Pages
111 - 111
Publication Date
2013/11/11
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2013.10.034How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - T.Q.S. Quinaglia
AU  - M.Z.B. Bensalah
AU  - E.B. Bollache
AU  - N.K. Kachenoura
AU  - L.M. Macron
AU  - P.B. Boutouyrie
AU  - S.L. Laurent
AU  - E.M. Mousseaux
PY  - 2013
DA  - 2013/11/11
TI  - P1.03 LEFT VENTRICULAR REMODELING: IMPACT OF GLOBAL, REGIONAL AND LOCAL AORTIC STIFFNESS
JO  - Artery Research
SP  - 111
EP  - 111
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.034
DO  - 10.1016/j.artres.2013.10.034
ID  - Quinaglia2013
ER  -