Artery Research

<Previous Article In Issue
Download article (PDF)
Next Article In Issue>
Volume 7, Issue 3-4, September 2013, Pages 111 - 111

P1.01 MARKER OF ARTERIAL STIFFNESS IN CHRONIC KIDNEY DISEASE – A PROSPECTIVE COHORT STUDY

Authors
Baumann Marcus1, Suttmann Yana1, Heemann Uwe1, Wassertheurer Siegfiried2
1Dept. of Nephrology, Klinikum rechts der Isar, TU Munich, Munich, Germany
2Health & Environment Department, AIT Austrian Institute of Technology, Vienna, Austria
Available Online 11 November 2013.
DOI
10.1016/j.artres.2013.10.032How to use a DOI?
Abstract

Objectives: Parameters associated with elevated arterial stiffness and structural vascular remodeling, like aortic pulse wave velocity, have been identified as important contributors to predict cardiovascular outcome in end stage renal disease but less is known about their value in early stages of chronic kidney disease (CKD).

Methods: In order to investigate the progression of arterial stiffness markers in CKD we prospectively studied a cohort of 135 (41% female) patients with CKD stages 2/3/4 (N=20/75/40), and 89 (49% female) controls by cross sectional analysis in a first step. Subsequently we were able to follow up 129 patients for an average period of 42 months to evaluate the predictive value of arterial stiffness by means of central hemodynamics, pulse pressure amplification (PPA) and aortic pulse wave velocity (aPWV). Renal endpoints were halving of renal function and/or start of renal replacement therapy.

Results: With respect to arterial function in cross sectional analysis augmentation index (AIx) and aortic pulse wave velocity (PWV) were significantly increased in CKD patients, whereas pulse pressure amplification (PPA) was reduced as compared to control subjects. In longitudinal analysis stratification according to CKD stage 2–4 PPA predicted renal endpoints whereas PWV was associated with mortality.

Conclusion: PPA and PWV have been evidenced as predictor for cardiovascular morbidity and mortality. Within this cohort PPA was associated with the progression of CKD and PWV with mortality.

Open Access
This is an open access article distributed under the CC BY-NC license.

<Previous Article In Issue
Download article (PDF)
Next Article In Issue>
Journal
Artery Research
Volume-Issue
7 - 3-4
Pages
111 - 111
Publication Date
2013/11/11
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2013.10.032How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Baumann Marcus
AU  - Suttmann Yana
AU  - Heemann Uwe
AU  - Wassertheurer Siegfiried
PY  - 2013
DA  - 2013/11/11
TI  - P1.01 MARKER OF ARTERIAL STIFFNESS IN CHRONIC KIDNEY DISEASE – A PROSPECTIVE COHORT STUDY
JO  - Artery Research
SP  - 111
EP  - 111
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.032
DO  - 10.1016/j.artres.2013.10.032
ID  - Marcus2013
ER  -