Artery Research

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Volume 25, Issue Supplement 1, December 2019, Pages S160 - S160

P120 Early Sympahovagal Imbalance Associates with Future Arrhythmic Events in Hypertensives

Authors
Dimitrios Terentes-Printzios*, Charalambos Vlachopoulos, Georgia Christopoulou, Lampros Korogiannis, Panos Xydis, Vasiliki Gardikioti, Eirini Solomou, Nikolaos Ioakeimidis, Christos Georgakopoulos, Ioanna Dima, Dimitrios Tousoulis
First Cardiology Department, National and Kapodistrian, University of Athens University Medical School, Hippokration Hospital, Athens, Greece
*Corresponding author. Email: dimitristerentes@yahoo.gr
Corresponding Author
Dimitrios Terentes-Printzios
Available Online 17 February 2020.
DOI
10.2991/artres.k.191224.146How to use a DOI?
Abstract

Purpose/Background/Objectives: Cardiac autonomic dysfunction is associated with increased cardiovascular mortality and arrhythmias. The aim of the study was to investigate the effect of heart rate variability (HRV) in the prognosis of future arrhythmic events.

Methods: We studied 292 untreated at baseline hypertensives (mean age 53 ± 13, 153 males). Cardiac autonomic function was evaluated by analysis of short-term HRV using 24-h ambulatory blood pressure monitoring and the standard deviation of measurements. Left ventricular mass index (LVMI) was estimated echocardiographically. Aortic stiffness was assessed with carotid-femoral pulse wave velocity (cfPWV) and aortic augmentation index corrected for heart rate (AIx@75). Patients were followed up for 13 years. The primary endpoint was a composite of atrial/ventricular tachycardias, symptomatic multiple premature ventricular contractions, second and third-degree heart blocks and pacemaker/defibrillator placement.

Results: Patients with the primary endpoint (n = 37.13%) had lower 24-h daytime HRV (9.6 beats per minute vs 11.1 beats per minute, p = 0.005), higher systolic blood pressure (168 mmHg vs 163 mmHg, p = 0.003), higher cfPWV (8.4 m/s vs 7.7 m/s, p = 0.005), higher LVMI (133 g/m2 vs 122 g/m2, p = 0.002) and higher AIx@75 (29.0% vs 26.3%, p = 0.043) compared to patients with no events. In Cox regression analysis, only higher HRV was associated with lower risk of arrhythmic events (Hazard ratio per 1 mmHg = 0.87, 95% Confidence intervals 0.76 to 0.995, p = 0.043) when adjusted for age, gender, cfPWV, LVMI and AIx@75.

Conclusion: Lower heart rate variability is associated with increased risk of future arrhythmic events suggesting an early sympathovagal imbalance that could lead to future events.

Copyright
© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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<Previous Article In Issue
Next Article In Issue>
Journal
Artery Research
Volume-Issue
25 - Supplement 1
Pages
S160 - S160
Publication Date
2020/02/17
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.2991/artres.k.191224.146How to use a DOI?
Copyright
© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - JOUR
AU  - Dimitrios Terentes-Printzios
AU  - Charalambos Vlachopoulos
AU  - Georgia Christopoulou
AU  - Lampros Korogiannis
AU  - Panos Xydis
AU  - Vasiliki Gardikioti
AU  - Eirini Solomou
AU  - Nikolaos Ioakeimidis
AU  - Christos Georgakopoulos
AU  - Ioanna Dima
AU  - Dimitrios Tousoulis
PY  - 2020
DA  - 2020/02/17
TI  - P120 Early Sympahovagal Imbalance Associates with Future Arrhythmic Events in Hypertensives
JO  - Artery Research
SP  - S160
EP  - S160
VL  - 25
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.191224.146
DO  - 10.2991/artres.k.191224.146
ID  - Terentes-Printzios2020
ER  -