Artery Research

<Previous Article In Issue
Next Article In Issue>
Volume 25, Issue Supplement 1, December 2019, Pages S91 - S91

P50 The Administration of Losartan/Amlodipine in Fixed Combination Versus Losartan Improves the Hemodynamic and Arterial Stiffness Parameters in Patients with Systemic Hypertension Grade 1 and 2

Authors
Mayra Jimenez*, Fernando Grover, Marycruz Barocio, Ernesto Cardona, Patricia Quezada, Jhonatan Trujillo, David Cardona, Carlos Ramos
Department of Physiology, Arterial Stiffness Laboratory, Experimental Therapeutic and Clinic Institute, Health Sciences University Center, University of Guadalajara, Guadalajara, Mexico
*Corresponding author. Email: mayrajimc16@gmail.com
Corresponding Author
Mayra Jimenez
Available Online 17 February 2020.
DOI
10.2991/artres.k.191224.081How to use a DOI?
Abstract

Purpose/Background/Objectives: Hypertension (HAS) represents 9.4 million deaths from all the cases of cardiovascular disease worldwide [1]. The pulse wave velocity (PWV) and some hemodynamic parameters have been associated with this outcome [2,3]. Losartan, as well as amlodipine, have shown benefits on hemodynamic parameters [4,5] however, it is unknown if losartan/amlodipine combination is better than losartan as a monotherapy. We evaluated losartan/amlodipine effect in a fixed combination versus losartan on hemodynamic and arterial stiffness parameters in patients with systemic arterial hypertension.

Design and Methods: We conducted a randomized, double-blind study in 28 hypertensive patients according to AHA criteria 2017 [6]. 14 patients received losartan 100 mg per day and 14 losartan/amlodipine 100/5 mg per day, for 8 weeks. Hemodynamic parameters and arterial stiffness measurement were performed with a Mobil-O-Graph® [7].

Results: The combination of losartan/amlodipine improved hemodynamic and arterial stiffness parameters compared with losartan, reducing peripheral vascular resistance (RVP) (0.10 ± 0.08 vs 0.05 ± 0.08), PWV (0.52 ± 0.45 vs 0.33 ± 0.359), daytime PWV (7.24 ± 0.90 vs 7.61 ± 1.03), nocturnal PWV (6.86 ± 0.96 vs 7.27 ± 1.17) and diastolic blood pressure (DBP) (11.21 ± 6.15 vs 5.92 ± 7.65).d)

Conclusion: We did not find differences between single or combined medication in terms of BP reduction. However, arterial stiffness parameters were better in the combined therapy.

Copyright
© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Download article (PDF)
View full text (HTML)

<Previous Article In Issue
Next Article In Issue>
Journal
Artery Research
Volume-Issue
25 - Supplement 1
Pages
S91 - S91
Publication Date
2020/02/17
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.2991/artres.k.191224.081How to use a DOI?
Copyright
© 2019 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - JOUR
AU  - Mayra Jimenez
AU  - Fernando Grover
AU  - Marycruz Barocio
AU  - Ernesto Cardona
AU  - Patricia Quezada
AU  - Jhonatan Trujillo
AU  - David Cardona
AU  - Carlos Ramos
PY  - 2020
DA  - 2020/02/17
TI  - P50 The Administration of Losartan/Amlodipine in Fixed Combination Versus Losartan Improves the Hemodynamic and Arterial Stiffness Parameters in Patients with Systemic Hypertension Grade 1 and 2
JO  - Artery Research
SP  - S91
EP  - S91
VL  - 25
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.191224.081
DO  - 10.2991/artres.k.191224.081
ID  - Jimenez2020
ER  -