P79 Non-invasive Estimation of Central Pressures in Abdominal Aortic Aneurysm Patients and Changes in PWV After EVAR

Suzanne Holewijn; Lennart van de Velde; Jenske Vermeulen; Michel Reijnen

doi:10.2991/artres.k.191224.109

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Volume 25, Issue Supplement 1, December 2019, Pages S122 - S122

P79 Non-invasive Estimation of Central Pressures in Abdominal Aortic Aneurysm Patients and Changes in PWV After EVAR

Authors

Suzanne Holewijn¹^{, *}, Lennart van de Velde²^{, 3}, Jenske Vermeulen⁴^{, 3}, Michel Reijnen³^{, 2}

¹Rijnstate, Vascular Research Center, Arnhem, Netherlands

²Multimodality Medical Imaging Group, Technical Medical Centre, University of Twente, Enschede

³Rijnstate, Department of Vascular Surgery, Arnhem, Netherlands

⁴RadboudUMC, Nijmegen, Netherlands

^*Corresponding author. Email: holewijnsuzanne@gmail.com

Corresponding Author

Suzanne Holewijn

Available Online 17 February 2020.

DOI: 10.2991/artres.k.191224.109 How to use a DOI?
Abstract: Background: Abdominal aortic aneurysm (AAA) disease is mainly treated by endovascular aneurysm repair (EVAR) and PWV has been shown to increase after EVAR. Arterial stiffness is predictive of cardiovascular disease, but has not been investigated in AAA-patients. We investigated if central pressures (CP) can be estimated correctly in AAA-patients and changes over time in pulse wave velocity (PWV), since PWV-changes during follow-up are currently unknown.

Methods: Non-invasive (SphygmoCor) and invasive waveform recordings were performed simultaneously before and after EVAR. A generalized ascending-to-abdominal aorta transfer function (GTFAA) was used to estimate CP from the invasively measured abdominal aorta pressure-waveform, and compared to the non-invasively estimated CP. Changes in PWV were evaluated compared to baseline (6-weeks and 1-year).

Results: The mean difference between invasive and non-invasive central systolic pressure was −11.5 mmHg (limits-of–agreement: −63.5; 40.6) before and 0.03 (−33.5; 33.6) after implant. For central diastolic and mean pressure mean difference was −12.2 (−39.3; 14.8) and −9.6 (−45.3; 26.1), respectively. Median (IQR) PWV was 10.5 (9.2; 13.2) at baseline, 10.5 (10.1; 12.4) at discharge, 11.5 (10.6; 12.9) at 6 weeks, and 11.3 (9.9; 13.0) at 1 year follow-up without significant differences over time. Increases in CP were equal to peripheral pressure increases.

Conclusion: Synthesizing CP with non-invasive measurements in combination with the use of a GTFAA in patients with AAA is feasible especially after EVAR. No changes over time in PWV were observed. Current ongoing analyses include evaluation by prosthesis type, wave type, and influence of intra-luminal thrombus (NCT01220245).
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Journal: Artery Research
Volume-Issue: 25 - Supplement 1
Pages: S122 - S122
Publication Date: 2020/02/17
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.2991/artres.k.191224.109 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

ris enw bib

TY  - JOUR
AU  - Suzanne Holewijn
AU  - Lennart van de Velde
AU  - Jenske Vermeulen
AU  - Michel Reijnen
PY  - 2020
DA  - 2020/02/17
TI  - P79 Non-invasive Estimation of Central Pressures in Abdominal Aortic Aneurysm Patients and Changes in PWV After EVAR
JO  - Artery Research
SP  - S122
EP  - S122
VL  - 25
IS  - Supplement 1
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.191224.109
DO  - 10.2991/artres.k.191224.109
ID  - Holewijn2020
ER  -

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