Artery Research

Volume 16, Issue C, December 2016, Pages 94 - 94

PO-17 ROLE OF NITRIC OXIDE IN β2-ADRENERGIC MEDIATED VASODILATION IN POSTMENOPAUSAL WOMEN

Authors
Sushant M. Ranadive, Roneé E. Harvey, Jacqueline K. Limberg, Timothy B. Curry, Wayne T. Nicholson, Michael J. Joyner
Department of Anesthesiology, Mayo Clinic, Rochester, MN, United States
Available Online 24 November 2016.
DOI
10.1016/j.artres.2016.08.024How to use a DOI?
Abstract

Objectives: Postmenopausal (PM) women have a blunted β2-adrenergic receptor-mediated responsiveness when compared to young premenopausal women in part due to a reduction in the relative contribution of nitric oxide (NO) to β2-adrenergic mediated vasodilation. Hence, we tested the contribution of NO to β2-adrenergic receptor-mediated vasodilation during terbutaline infusion.

Hypothesis: We hypothesized that the contribution of NO to β2-adrenergic mediated vasodilation would be attenuated in PM women as compared to young women.

Methods: Venous occlusion plethysmography was used to measure forearm blood flow (FBF) in 7 healthy young premenopausal women and 9 healthy PM women (mean age = 27 ± 1 and 60 ± 1 years, respectively). FBF was measured at baseline and during terbutaline infusion at 0.1, 0.5, 1.0, 2.0 μg/100ml tissue/min before (with saline co-infusion) and during NO synthase inhibition with L-NMMA. Forearm vascular conductance was calculated from FBF and mean arterial pressure.

Results: In young women, there was a significant L-NMMA effect on forearm vascular conductance during terbutaline infusion with and without L-NMMA (1.7 ± 0.14, 3.56 ± 0.41, 7.13 ± 1.11, 7.87 ± 0.74, 10.54 ± 1.81 versus 2.08 ± 0.28, 5.54 ± 0.50, 9.32 ± 1.10, 10.77 ± 1.49, 13.29 ± 1.94 ml/100ml tissue/min/mmHg, respectively). However, there was no effect of L-NMMA in PM women during terbutaline infusion with and without L-NMMA (1.34 ± 0.26, 2.37 ± 0.32, 5.21 ± 0.99, 4.71 ± 0.99, 6.43 ± 1.37 versus 1.62 ± 0.31, 3.11 ± 0.55, 5.41 ± 1.12, 6.26 ± 1.38, 7.26 ± 1.44 ml/100ml tissue/min/mmHg, respectively).

Conclusions: These data suggest that NO contributes to β2-adrenergic mediated vasodilation in young premenopausal women. In contrast, no contribution of NO to β2 mediated vasodilation was observed in PM women. These data suggest a lower β2-adrenergic responsiveness in PM women may be due to a reduced contribution of NO.

Open Access
This is an open access article distributed under the CC BY-NC license.

Journal
Artery Research
Volume-Issue
16 - C
Pages
94 - 94
Publication Date
2016/11/24
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2016.08.024How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Sushant M. Ranadive
AU  - Roneé E. Harvey
AU  - Jacqueline K. Limberg
AU  - Timothy B. Curry
AU  - Wayne T. Nicholson
AU  - Michael J. Joyner
PY  - 2016
DA  - 2016/11/24
TI  - PO-17 ROLE OF NITRIC OXIDE IN β2-ADRENERGIC MEDIATED VASODILATION IN POSTMENOPAUSAL WOMEN
JO  - Artery Research
SP  - 94
EP  - 94
VL  - 16
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2016.08.024
DO  - 10.1016/j.artres.2016.08.024
ID  - Ranadive2016
ER  -