Artery Research

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Volume 16, Issue C, December 2016, Pages 88 - 88

15.9 MODELLING ARTERIAL PULSE PRESSURE FROM HEART RATE DURING SYMPATHETIC ACTIVATION

Authors
Bjorn van der Ster1, Berend Westerhof1, Wim Stok1, Feras Hatib2, Jos Settels2, Johannes van Lieshout1
1Academic Medical Center, Amsterdam, Netherlands
2Edwards Lifesciences, Irvine, CA, USA
Available Online 24 November 2016.
DOI
10.1016/j.artres.2016.10.140How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Background: The duration of the time segment between the systolic (SP) and post-dicrotic notch peak pressures (PDP) of the arterial pressure wave in humans has been proposed to be related to arterial pulse pressure (PP).1,2 We considered an effect of RR-interval length on the diastolic pressure run-off and tested the hypothesis that heart rate (HR) affects the timing of systolic and post-dicrotic notch peak pressures.

Methods: We modelled the effects of sympathetic stimulation by progressive central hypovolemia on PP changes based on morphological features of a peripherally measured arterial blood pressure wave shape and HR, making use of linear mixed effect (LME) models. Changes of the arterial pulse wave were tracked from rest towards central hypovolemia in 44 subjects by exposing them to continuous –50 mmHg lower body negative pressure (LBNP). SP and PDP, and HR were extracted from arterial finger pressure and used as model input to predict PP.

Results: From rest to sympathetic stimulation, HR (30%) and thoracic impedance (15%) increased and systolic (SAP) fell by 10%. Model errors of PP (median, and 1stand 3rd quartiles) were 5.2 [3.3 8.9], 4.9 [3.8 7.7], and 4.9 [3.7 8.6] for LME models of, respectively, SP-PDP, HR and their combination.

Conclusion: Our study highlights that during sympathetic stimulation by progressive central hypervolaemia, HR affects arterial pressure wave characteristics and that linear models from both HR and SP-PDP duration allow for estimating PP.

References

1.MC Baruch, K Kalantari, DW Gerdt, and CM Adkins, Validation of the pulse decomposition analysis algorithm using central arterial blood pressure, Biomedical engineering online 13, 2014, pp. 96.
2.MC Baruch, DE Warburton, SS Bredin, A Cote, DW Gerdt, and CM Adkins, Pulse Decomposition Analysis of the digital arterial pulse during hemorrhage simulation, Nonlinear Biomed Phys, Vol. 5, 2011, pp. 1.
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Journal
Artery Research
Volume-Issue
16 - C
Pages
88 - 88
Publication Date
2016/11/24
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2016.10.140How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Bjorn van der Ster
AU  - Berend Westerhof
AU  - Wim Stok
AU  - Feras Hatib
AU  - Jos Settels
AU  - Johannes van Lieshout
PY  - 2016
DA  - 2016/11/24
TI  - 15.9 MODELLING ARTERIAL PULSE PRESSURE FROM HEART RATE DURING SYMPATHETIC ACTIVATION
JO  - Artery Research
SP  - 88
EP  - 88
VL  - 16
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2016.10.140
DO  - 10.1016/j.artres.2016.10.140
ID  - vanderSter2016
ER  -