Artery Research

Volume 16, Issue C, December 2016, Pages 62 - 62

7.2 POOR SLEEP QUALITY RELATED TO WORSE VASCULAR FUNCTION IN INDIVIDUALS WITH MULTIPLE SCLEROSIS

Authors
Thessa Hilgenkamp1, Garett Griffith1, Robert Motl2, Tracy Baynard1, Bo Fernhall1
1University of Illinois at Chicago, USA
2University of Illinois at Urbana-Champaign, USA
Available Online 24 November 2016.
DOI
10.1016/j.artres.2016.10.048How to use a DOI?
Abstract

Background: Poor sleep quality has been related to poor vascular function and higher risk of cardiovascular disease in the general population. Persons with multiple sclerosis (MS) exhibit a high cardiovascular risk, and report poor sleep quality. To date, the association between sleep quality and vascular health in MS has not been investigated. Objective: To investigate differences in vascular health between good and poor quality sleepers with MS. Methods: After a 10 minute rest in the supine position, resting heart rate (HR) and brachial blood pressure (BP) were collected.Aortic SBP, augmentation index (AIX), HR normalized AIX (AIX@HR75), subendocardial viability ratio (SEVR), end systolic pressure (ESP), and central pulse wave velocity (PWVc) were measured with applanation tonometry in individuals with MS (n=49). Carotid intima-media thickness (IMT) and beta-stiffness were measured with carotid ultrasound, and peak forearm blood flow (FBF Peak) was measured with strain gauge plethysmography. Sleep quality was measured with the Pittsburgh Sleep Quality Index (>5 was categorized as poor sleep quality). Age was used as a covariate.

Results: AIX@HR75 and SEVR were different between groups, even with age as a covariate, suggesting higher vascular risk for the poor quality sleepers with MS.

Conclusions: This study shows that within the MS population, poor quality sleepers have a higher cardiovascular risk than good quality sleepers. Whether poor sleep raises their cardiovascular risk more than in the general population is an area of future investigation.

Good quality sleepers with MS (n=23) Poor quality sleepers with MS (n=26) Effect of sleep quality Effect of age




Mean (SD) Mean (SD) p Partial Eta2 p Partial Eta2
N Female (%) 18 (75%) 22 (82%)
PSQI score 2.9 (1.5) 9.7 (3.1)
Age 44 ±13 52 ±10
BMI 26.9 ±5.4 28.1± 5.6 .582 0.007 .584 0.007
HR 64 ±10 65± 8 .136 0.048 .014* 0.125
SBP 116 ±14 122 ±14 .384 0.017 .025* 0.105
DBP 72 ±9 74 ±10 .457 0.012 .559 0.007
MAP 86± 10 90 ±11 .403 0.015 .175 0.040
Aortic SBP 106 ±14 114 ±14 .223 0.032 .001** 0.200
AIX 21.1 ±13.7 30.0± 9.0 .082 0.064 <.001** 0.282
AIX@HR75 15.1± 12.0 25.5± 7.6 .007** 0.150 .001** 0.211
SEVR 158± 21 147 ±18 .026* 0.103 .160 0.042
ESP 96 ±12 103± 14 .213 0.034 .007** 0.148
PWVc 6.7± 1.4 7.5± 1.4 .200 0.036 .007** 0.146
PWVc/MAP 0.078± 0.014 0.084 ±0.016 .376 0.017 .063 0.073
IMT 0.51± 0.11 0.53 ±0.12 .571 0.007 <.001** 0.342
Beta 7.3 ±2.3 8.1± 2.7 .785 0.002 .002** 0.193
FBF Peak 17.8 4.4 17.2 6.6 .988 0.000 .185 0.038
*

p<0.05

**

p<0.01

Open Access
This is an open access article distributed under the CC BY-NC license.

Journal
Artery Research
Volume-Issue
16 - C
Pages
62 - 62
Publication Date
2016/11/24
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2016.10.048How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Thessa Hilgenkamp
AU  - Garett Griffith
AU  - Robert Motl
AU  - Tracy Baynard
AU  - Bo Fernhall
PY  - 2016
DA  - 2016/11/24
TI  - 7.2 POOR SLEEP QUALITY RELATED TO WORSE VASCULAR FUNCTION IN INDIVIDUALS WITH MULTIPLE SCLEROSIS
JO  - Artery Research
SP  - 62
EP  - 62
VL  - 16
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2016.10.048
DO  - 10.1016/j.artres.2016.10.048
ID  - Hilgenkamp2016
ER  -