Artery Research

Volume 16, Issue C, December 2016, Pages 57 - 58

5.5 AGE-DEPENDENT TELOMERE ATTRITION, SHORT TELOMERES AND ATHEROSCLEROSIS

Authors
Simon Toupance1, Anna Kearney-Schwartz2, Mohamed Temmar3, Cécile Lakomy1, Carlos Labat1, Patrick Rossignol4, Faiez Zannad4, Patrick Lacolley1, Abraham Aviv5, Athanase Benetos2
1INSERM UMRS 1116, Université de Lorraine, Nancy, France
2Département de Médecine Gériatrique, CHU de Nancy, France
3Cardiology Center, Ghardaia, Algeria
4CIC-P Pierre Drouin, CHU de Nancy, France
5Center of Human Development and Aging, Rutgers University, NJ, USA
Available Online 24 November 2016.
DOI
10.1016/j.artres.2016.10.033How to use a DOI?
Abstract

Background: Short leukocyte telomere length (LTL) is associated with atherosclerosis. The prevailing view is this association exists since LTL is a biomarker of cumulative inflammation and oxidative stress during adult life. However recent studies show that LTL in adults is defined mainly by LTL at birth and attrition during childhood. Therefore we can suggest that short LTL might precede clinical expression of atherosclerosis.

Objectives: To examine the directionality in the relation between carotid atheroma and LTL dynamics.

Methods: LTL was measured by TRF in samples donated 9 years apart on average by 257 men and women aged 41 to 80 at the inclusion.

Results: LTL attrition during follow-up (FU) period was 25±17 bp/year. No relation was observed between LTL attrition and presence of carotid atherosclerotic plaques (PCAP). Baseline (BL)-LTL was highly correlated (r=0.96, p<0.0001) with FU-LTL. In 87.9%of the subjects LTL ranking by deciles was the same 1 decile at BL and FU. BL- and FU-LTL were inversely associated with PCAP (p<0.01). After adjusting for age and gender, BL-LTL was 6.50±0.04 Kb in subjects without PCAP 6.46±0.06 in those with PCAP only at the FU visit and 6.27±0.06 in those with PCAP in both BL and FU visits (p=0.027). LTL attrition was the same in these groups.

Conclusions: LTL attrition in adulthood is not influenced by PCAP and does not play a significant role in LTL ranking. By contrast, patients with shorter telomeres present CAP earlier in life. Telomere length could be considered as a bio-determinant for atherosclerosis.

Open Access
This is an open access article distributed under the CC BY-NC license.

Journal
Artery Research
Volume-Issue
16 - C
Pages
57 - 58
Publication Date
2016/11/24
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2016.10.033How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Simon Toupance
AU  - Anna Kearney-Schwartz
AU  - Mohamed Temmar
AU  - Cécile Lakomy
AU  - Carlos Labat
AU  - Patrick Rossignol
AU  - Faiez Zannad
AU  - Patrick Lacolley
AU  - Abraham Aviv
AU  - Athanase Benetos
PY  - 2016
DA  - 2016/11/24
TI  - 5.5 AGE-DEPENDENT TELOMERE ATTRITION, SHORT TELOMERES AND ATHEROSCLEROSIS
JO  - Artery Research
SP  - 57
EP  - 58
VL  - 16
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2016.10.033
DO  - 10.1016/j.artres.2016.10.033
ID  - Toupance2016
ER  -