4.2 WITHDRAWAL OF STATINS THERAPY IN PATIENTS AFTER CAROTID ENDARTERECTOMY ASSOCIATED WITH INCREASING RISK OF SIGNIFICANT RESTENOSIS

DOI

10.1016/j.artres.2016.10.021How to use a DOI?

Abstract

Background: The benefit of carotid revascularization is decreased by the occurrence of restenosis at the site of surgery, which is associated with a modestly increased risk of stroke. Preventing restenosis plays pivotal role in the overall treatment and prevention of stroke in patients with carotid artery disease.

Purpose: To evaluate influence of discontinuing of statins therapy on occurrence of restenosis in patients after carotid endarterectomy.

Methods: We studied 240 patients after carotid endarterectomy, mean age – 64.4±6.8 years. All the patients were divided into two groups: 1 group comprised 124 patients, who had taken atorvastatin in dose 10–40 mg daily and 2 group – 116 patients who discontinued statins therapy due complication 3 %, poor tolerance 9% or personal reluctance 88%. All the patients also underwent serial standardized ultrasound examination on 1, 3, 6, 12 month during first year after operation and then annually. Mean observation time was 5.6±2.1 years. Significant restenosis carotid artery (more than 70%) was established by standard Doppler velocity criteria.

Results: The significant restenosis of internal carotid artery was found in 2,4% patients with statins therapy and in 7,8% patients without statins. Statins withdrawal increased the incidence of late significant restenosis of internal carotid artery (odd ratio: 3.393 95% confidence interval: 0.895–12.857). Patients with withdrawal of statins had higher wall thickness: 4.3±0.8 against 2.9±0.9 (#1088 p<0,05).

Conclusion: Withdrawal of statins therapy in patients after carotid endarterectomy associated with increasing risk of significant restenosis carotid artery.

Open Access

This is an open access article distributed under the CC BY-NC license.

TY  - JOUR
AU  - Olga Tereshina
AU  - Alexcey Vachev
PY  - 2016
DA  - 2016/11/24
TI  - 4.2 WITHDRAWAL OF STATINS THERAPY IN PATIENTS AFTER CAROTID ENDARTERECTOMY ASSOCIATED WITH INCREASING RISK OF SIGNIFICANT RESTENOSIS
JO  - Artery Research
SP  - 54
EP  - 54
VL  - 16
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2016.10.021
DO  - 10.1016/j.artres.2016.10.021
ID  - Tereshina2016
ER  -