Artery Research

<Previous Article In Issue
Download article (PDF)
Next Article In Issue>
Volume 16, Issue C, December 2016, Pages 52 - 53

3.8 CAN ARTERIAL WAVE AUGMENTATION IN YOUNG ADULTS EXPLAIN VARIABILITY OF CARDIOVASCULAR RISK IN ETHNIC MINORITIES?

Authors
Luca Faconti1, 2, 3
1Cardiovascular and Social Epidemiology Groups, Diabetes and Nutritional Sciences Division, King’s College, London, UK
2Social and Public Health Sciences Unit, University of Glasgow, UK
3Institute for Applied Health Research, Glasgow Caledonian University, Glasgow, UK
Available Online 24 November 2016.
DOI
10.1016/j.artres.2016.10.018How to use a DOI?
Abstract

Objective: Traditional cardiovascular (CV) risk factors do not fully explain ethnic differences in CV disease [1,2]. We tested if pulse wave velocity (PWV) and Augmentation Index (AIx) and their determinants from childhood may underlie ethnic variability in CV risk as young adults in the ‘DASH’ longitudinal study.

Methods: DASH, at http://dash.sphsu.mrc.ac.uk/, includes representative samples of 6 main UK ethnic groups [3]. PWV and AIx were recorded using Arteriograph device at ages 21–23y in a sub-sample (n=666) psychosocial, anthropometric and blood pressure (BP) measures were collected then and in 2 previous surveys at the age of 11–13y and 14–16y. For n=334, physical activity (PA) was measured over 5 days (ActivPal).

Results: Unadjusted values and regression models for PWVs were similar or lower in ethnic minority than in White UK young adults [4], while AIx was higher - Caribbean (14.9, 95%CI 12.3–17.0, %), West African (15.3, 12.9–17.7, %), Indian (15.1, 13.0–17.2, %) and Pakistani/Bangladeshi (15.7, 13.7–17.7, %), compared with White UK (11.9, 10.2–13.6, %). In multivariate models, adjusted for gender, central sysBP, height and heart rate, Indian and Pakistani/Bangladeshi young adults had higher AIx (β=3.35, 4.20 respectively, p<0.01) than White UK with a similar trend for West Africans and Caribbeans but not statistically significant. Unlike PWV, PA, psychosocial or deprivation measures were not associated with AIx, with borderline associations from brachial BP but no other childhood variables.

Conclusion: Early adult AIx, but not arterial stiffness, may be a useful tool for testing components of excess CV risk in some ethnic minority groups.

Open Access
This is an open access article distributed under the CC BY-NC license.

References

1.SH Wild, C Fischbacher, A Brock, C Griffiths, and R Bhopal, Mortality from all causes and circulatory disease by country of birth in England and Wales 2001–2003, J Public Health (Oxf), Vol. 29, 2007, pp. 191-198.
2.T Tillin, AD Hughes, J Mayet, P Whincup, N Sattar, NG Forouhi, et al., The Relationship Between Metabolic Risk Factors and Incident Cardiovascular Disease in Europeans, South Asians, and African Caribbeans SABRE (Southall and Brent Revisited) a prospective population-based study, J Am Coll Cardiol, Vol. 61, 2013, pp. 1777-1786.
3.S Harding, M Whitrow, MJ Maynard, and A Teyhan, Cohort profile: The DASH (Determinants of Adolescent Social well-being and Health) Study, an ethnically diverse cohort, Int. J. Epidemiol, Vol. 36, 2007, pp. 512-517.
4.JK Cruickshank, M Silva, O Molaodi, Z Enayat, A Cassidy, A Karamanos, et al., Ethnic differences in and childhood influences on early adult PWV: the DASH longitudinal study, Hypertension, Vol. 67, 2016. 00-00
<Previous Article In Issue
Download article (PDF)
Next Article In Issue>
Journal
Artery Research
Volume-Issue
16 - C
Pages
52 - 53
Publication Date
2016/11/24
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2016.10.018How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Luca Faconti
PY  - 2016
DA  - 2016/11/24
TI  - 3.8 CAN ARTERIAL WAVE AUGMENTATION IN YOUNG ADULTS EXPLAIN VARIABILITY OF CARDIOVASCULAR RISK IN ETHNIC MINORITIES?
JO  - Artery Research
SP  - 52
EP  - 53
VL  - 16
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2016.10.018
DO  - 10.1016/j.artres.2016.10.018
ID  - Faconti2016
ER  -