P168 FEASIBILITY STUDY OF LOCAL PULSE WAVE VELOCITY ESTIMATION IN THE CAROTID ARTERY WITH MULTI-BEAM LASER DOPPLER VIBROMETER

Daniela Tommasin; Yanlu Li; Jonathan Reeves; Roel Baets; Steve Greenwald; Patrick Segers

doi:10.1016/j.artres.2018.10.221

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Volume 24, Issue C, December 2018, Pages 129 - 130

P168 FEASIBILITY STUDY OF LOCAL PULSE WAVE VELOCITY ESTIMATION IN THE CAROTID ARTERY WITH MULTI-BEAM LASER DOPPLER VIBROMETER

Authors

Daniela Tommasin¹, Yanlu Li²^{, 3}, Jonathan Reeves⁴^{, 5}, Roel Baets²^{, 3}, Steve Greenwald⁴, Patrick Segers¹

¹IBiTech-bioMMeda, Ghent University, Ghent, Belgium

²Photonics Research Group, INTEC -department, Ghent University - IMEC, Ghent, Belgium

³Center for Nano- and Biophotonics, Ghent University, Ghent, Belgium

⁴Blizard Institute, Queen Mary University of London, London, UK

⁵Clinical Physics, Barts Health Trust, London, UK

Available Online 4 December 2018.

DOI: 10.1016/j.artres.2018.10.221 How to use a DOI?
Abstract: Background: An innovative device using Laser Doppler Vibrometry (LDV) has been designed [1] to measure the transit time of the pulse wave between two locations along the course of the carotid artery (CA) from skin surface vibrations for assessment of local pulse wave velocity (PWV) [2]. Aim: Tests were conducted on in-vitro models to assess the feasibility of the LDV to estimate the local PWV; preliminary in-vivo measurements were also performed.

Methods: Two CA geometries embedded within a soft-tissue-mimicking hydrogel were considered: i) a straight latex tube and ii) a patient-specific CA silicone-rubber model including the bifurcation. Models were pressurised in a water-filled loop and pulsatile flow was generated with a pump and/or high frequency impulses induced externally. For all measurements, two sets of six beams were used to measure surface displacement perpendicular to the external surface. PWV was calculated from the distance between selected beams and the delay between corresponding signals, using the time of the maximum of first and second derivatives of pressure (P-PWV) and displacement (LDV-PWV) as fiducial points [3]. A windowed cross correlation method [4] was also used for the in-vivo data analysis.

Results: PWV values for the in-vitro models are summarized in Table 1, while preliminary in-vivo LDV-PWV results are shown in Fig 1.

Table 1
P-PWV and LDV-PWV mean values under pulsatile flow and induced impulse conditions.

Conclusions: Good agreement between P-PWV and LDV-PWV in the tubular model was found under impulse loading, while complex waveforms measured under pulsatile flow and in-vivo conditions lead to more disparate effects when using different analysis methods. Further signal analysis is warranted.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 24 - C
Pages: 129 - 130
Publication Date: 2018/12/04
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2018.10.221 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - Daniela Tommasin
AU  - Yanlu Li
AU  - Jonathan Reeves
AU  - Roel Baets
AU  - Steve Greenwald
AU  - Patrick Segers
PY  - 2018
DA  - 2018/12/04
TI  - P168 FEASIBILITY STUDY OF LOCAL PULSE WAVE VELOCITY ESTIMATION IN THE CAROTID ARTERY WITH MULTI-BEAM LASER DOPPLER VIBROMETER
JO  - Artery Research
SP  - 129
EP  - 130
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.221
DO  - 10.1016/j.artres.2018.10.221
ID  - Tommasin2018
ER  -

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