Artery Research

Volume 24, Issue C, December 2018, Pages 120 - 120

P141 TELOMERE DYNAMICS RELATION WITH OBESITY

Authors
Simon Toupance1, Mirna Chahine2, Irini Tzanetakou3, Carlos Labat4, Sylvie Gautier1, Cécilé Lakomy4, Pascal Rossi5, Toufic Moussallem6, Pierre Yared6, Didier Quilliot7, Evangelos Menenakos8, Roland Asmar2, Athanase Benetos1, 4
1Department of Geriatrics, University Hospital of Nancy, Nancy, France
2Foundation-Medical Research Institutes, Beirut, Lebanon
3European University of Cyprus, School of Sciences, Engomi, Cyprus
4Inserm UMRS 1116, University of Lorraine, Nancy, France
5North hospital, APHM, Marseille, France
6Faculty of Medical Sciences, Lebanese University, Hadath, Lebanon
7Department of Endocrinolgy, University Hospital of Nancy, Nancy, France
8Medical School of Athens, National and Kapodistrian University of Athens, Greece
Available Online 4 December 2018.
DOI
10.1016/j.artres.2018.10.194How to use a DOI?
Abstract

Background: The relation between telomere dynamics and obesity remains unclear. Cross-sectional studies found associations between short leukocyte telomere length (LTL) and high body mass index (BMI) but longitudinal studies did not find any association between LTL attrition and BMI. In two parallel studies, we aimed to assess the relationship between obesity and telomere dynamics in different tissues.

Methods: Study 1: Measurements of LTL and TL in skeletal muscle (MTL) were performed in 53 subjects with severe obesity (BMI > 35) and in 53 age- and sex-matched without obesity (21 < BMI < 30). MTL is a proxy of TL at birth and the LTL/MTL ratio represents life-long telomere attrition. Study 2: Measurements of TL in subcutaneous fat (SCF), a high proliferative adipose tissue, and visceral fat (VF), a low proliferative one in 50 severe obese bariatric patients. TL measurements were performed by Southern blot.

Results: Study 1: In younger (<55 years), but not in older, LTL and LTL/MTL were shorter in obese patients vs controls (7.16 kb vs 7.54 kb, p < 0.05 for LTL and 81% vs 84%, p < 0.05 for LTL/MTL). Study 2: Within obese bariatric patients, SCF/VF TL ratio was lower in those with early onset obesity (96% for obesity since childhood vs 97% since adolescence vs 100% for adult development of obesity; p < 0.05).

Conclusions: Early life obesity is associated with higher TL attrition leading to shorter TL in high proliferative tissues.

Open Access
This is an open access article distributed under the CC BY-NC license.

Journal
Artery Research
Volume-Issue
24 - C
Pages
120 - 120
Publication Date
2018/12/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2018.10.194How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Simon Toupance
AU  - Mirna Chahine
AU  - Irini Tzanetakou
AU  - Carlos Labat
AU  - Sylvie Gautier
AU  - Cécilé Lakomy
AU  - Pascal Rossi
AU  - Toufic Moussallem
AU  - Pierre Yared
AU  - Didier Quilliot
AU  - Evangelos Menenakos
AU  - Roland Asmar
AU  - Athanase Benetos
PY  - 2018
DA  - 2018/12/04
TI  - P141 TELOMERE DYNAMICS RELATION WITH OBESITY
JO  - Artery Research
SP  - 120
EP  - 120
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.194
DO  - 10.1016/j.artres.2018.10.194
ID  - Toupance2018
ER  -