P107 RENAL DENERVATION IMPROVES 24-HOUR CENTRAL AND PERIPHERAL BLOOD PRESSURES, ARTERIAL STIFFNESS AND PERIPHERAL RESISTANCE

Christian Ott; Klaas Franzen; Tobias Graf; Joachim Weil; Roland Schmieder; Michael Reppel; Kai Mortensen

doi:10.1016/j.artres.2018.10.160

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Volume 24, Issue C, December 2018, Pages 110 - 110

P107 RENAL DENERVATION IMPROVES 24-HOUR CENTRAL AND PERIPHERAL BLOOD PRESSURES, ARTERIAL STIFFNESS AND PERIPHERAL RESISTANCE

Authors

Christian Ott¹, Klaas Franzen², Tobias Graf³, Joachim Weil⁴, Roland Schmieder⁵, Michael Reppel⁶, Kai Mortensen⁷

¹Department of Nephrology and Hypertension, University of Erlangen-Nürnberg, Erlangen, Germany

²Medizinische Klinik III, Campus Lübeck, Universitätsklinikum Schleswig-Holstein, Lübeck, Germany

³Medizinische Klinik II, Campus Lübeck, Universitätsklinikum Schleswig-Holstein, Lübeck, Germany

⁴Sana Kliniken Lübeck, Lübeck, Germany

⁵Department of Nephrology and Hypertension, University or Erlangen-Nürnberg, Erlangen, Germany

⁶Cardiology Landsberg, Landsberg, Germany

⁷Cardiology Practice, Kiel, Germany

Available Online 4 December 2018.

DOI: 10.1016/j.artres.2018.10.160 How to use a DOI?
Abstract: Background: Ambulatory Blood Pressure (BP) as well as central BP are better predictors for overall cardiovascular risk and mortality than brachial BP. Renal Denervation (RDN) has been shown to reduce office brachial and central BP as well as ambulatory brachial BP, but data on central ambulatory BP are limited. We therefore aimed to study the effect of RDN also on central hemodynamics assessed under ambulatory conditions.

Methods: In total 94 patients with treatment resistant hypertension (TRH) (office BP ≥140/90 mmHg, and diagnosis confirmed by mean daytime brachial ambulatory BP ≥135/85 mmHg) who underwent RDN (using Medtronic Symplicity™ RDN radiofrequency ablation catheter system) were included. Ambulatory BP, including central pressures, hemodynamics and arterial stiffness, were measured at baseline and 3, 6, 12 months after RDN by an oscillometric device (MobiloGraph™, I.E.M., Germany).

Results: Office BP was significantly reduced at all time points (p for all <0.001). At 3, 6 and 12 months follow-up, brachial ambulatory BP was reduced by 6 ± 13/4 ± 7 mmHg, 8 ± 15/4 ± 10 mmHg, 9 ± 16/4 ± 9 mmHg, respectively (p for all <0.001). Consistently, central ambulatory BP was reduced by 6 ± 12/3 ± 8 mmHg, 7 ± 15/4 ± 9 mmHg, 9 ± 15/5 ± 9 mmHg, respectively (p for all <0.001). In addition, ambulatory assessed averaged daytime pulse wave velocity improved after RDN (p < 0.05). Total vascular resistance decreased by 4.0 %/5.5 %/6.7 % (p for all <0.01). In contrast, cardiac output was not altered during follow-up.

Conclusion: In patients with TRH, RDN improves brachial and central ambulatory BP, arterial stiffness and total vascular resistance, indicating an improvement of cardiovascular outcome.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 24 - C
Pages: 110 - 110
Publication Date: 2018/12/04
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2018.10.160 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - Christian Ott
AU  - Klaas Franzen
AU  - Tobias Graf
AU  - Joachim Weil
AU  - Roland Schmieder
AU  - Michael Reppel
AU  - Kai Mortensen
PY  - 2018
DA  - 2018/12/04
TI  - P107 RENAL DENERVATION IMPROVES 24-HOUR CENTRAL AND PERIPHERAL BLOOD PRESSURES, ARTERIAL STIFFNESS AND PERIPHERAL RESISTANCE
JO  - Artery Research
SP  - 110
EP  - 110
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.160
DO  - 10.1016/j.artres.2018.10.160
ID  - Ott2018
ER  -

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