P104 INFLUENCE OF AGE AND GENDER ON 24-HOUR VARIABILITY OF CENTRAL BLOOD PRESSURE: FINDINGS FROM THE INTERNATIONAL 24-HOUR AMBULATORY AORTIC BLOOD PRESSURE CONSORTIUM (I24ABC)

Thomas Weber; Athanase Protogerou; Siegfried Wassertheurer; Cristina Giannatasio; Piotr Jankowski; Yan Li; Alessandro Maloberti; Barry McDonnell; Carmel McEniery; Maria Lorenza Muiesan; Janos Nemcsik; Anna Paini; Enrique Rodilla; Ian Wilkinson; Robert Zweiker; James Sharman

doi:10.1016/j.artres.2018.10.157

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Volume 24, Issue C, December 2018, Pages 109 - 109

P104 INFLUENCE OF AGE AND GENDER ON 24-HOUR VARIABILITY OF CENTRAL BLOOD PRESSURE: FINDINGS FROM THE INTERNATIONAL 24-HOUR AMBULATORY AORTIC BLOOD PRESSURE CONSORTIUM (I24ABC)

Authors

Thomas Weber¹, Athanase Protogerou², Siegfried Wassertheurer³, Cristina Giannatasio⁴, Piotr Jankowski⁵, Yan Li⁶, Alessandro Maloberti⁴, Barry McDonnell⁷, Carmel McEniery⁸, Maria Lorenza Muiesan⁹, Janos Nemcsik¹⁰, Anna Paini⁹, Enrique Rodilla¹¹, Ian Wilkinson⁸, Robert Zweiker¹², James Sharman¹³

¹Cardiology Department, Klinikum Wels-Grieskirchen, Wels, Austria

²Department of Pathophysiology Medical School National and Kapodistrian University of Athens, Greece

³Health & Environment Department, Austrian Institute of Technology, Vienna, Austria

⁴University Milano-Bicocca, MIlano, Italy

⁵Jagellonian University, Krakow, Poland

⁶Shanghai Institute of Hypertension, Shanghai Jiaotong University School of Medicine, Shanghai, China

⁷Cardiff Metropolitan University, Cardiff, UK

⁸Experimental Medicine and Immunotherapeutics, University of Cambridge, Cambridge, UK

⁹Dipartimento di Scienze Cliniche e Sperimentali, Università di Brescia, Brescia, Italy

¹⁰Semmelweis University, Budapest, Hungary

¹¹Hospital de Sagunto, Universidad CEU Cardenal Herrera, Valencia, Spain

¹²Department of Cardiology, Medical University Graz, Graz, Austria

¹³Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia

Available Online 4 December 2018.

DOI: 10.1016/j.artres.2018.10.157 How to use a DOI?
Abstract: Background: Conventional brachial cuff BP is known to vary according to age and gender, but the influence of these factors on 24-hour ambulatory central BP is unknown. We sought to determine this in a large healthy population from 11 centers in Europe and Asia.

Methods: 24-hour ambulatory BP using a validated oscillometric device (Mobilograph, I.E.M, Stolberg, Germany) was performed in 1645 individuals free from antihypertensive drugs. Participants were categorized as young (Y: 13–39 years; M/F:219/112), middle-aged (MA: 40–66 years; M/F:545/553), and older (O: 67–104 years; M/F:86/130). Nighttime/daytime difference (N/D) was defined as nighttime (01.00–06.00) minus daytime (09.00–21.00) values / daytime values.

Results: Averaged 24-hour brachial BP was 125/79 (Y), 128/83 (MA), and 127/77 (O) mmHg. N/D for brachial SBP was −10.3% (Y), −6.4% (MA), and −4.7% (O), but was significantly less pronounced for central SBP: −1% (Y), −3.1% (MA), and −1.9% (O). Men, compared to women, had higher brachial and central SBPs, mainly in younger participants. Brachial pulse pressure (PP) displayed limited and age-dependent circadian variations, whereas central PP was substantially higher at nighttime: N/D was 24% (Y), 9% (MA), and 5.9% (O). Brachial and central PPs were higher in men in the younger group, but higher in women in middle-aged and older groups.

Conclusion: Both age and gender each have a significant influence on 24-hour variability of central BP, but is different than variability in brachial BP. These data have potential implications for refining hypertension diagnosis and management.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 24 - C
Pages: 109 - 109
Publication Date: 2018/12/04
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2018.10.157 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - Thomas Weber
AU  - Athanase Protogerou
AU  - Siegfried Wassertheurer
AU  - Cristina Giannatasio
AU  - Piotr Jankowski
AU  - Yan Li
AU  - Alessandro Maloberti
AU  - Barry McDonnell
AU  - Carmel McEniery
AU  - Maria Lorenza Muiesan
AU  - Janos Nemcsik
AU  - Anna Paini
AU  - Enrique Rodilla
AU  - Ian Wilkinson
AU  - Robert Zweiker
AU  - James Sharman
PY  - 2018
DA  - 2018/12/04
TI  - P104 INFLUENCE OF AGE AND GENDER ON 24-HOUR VARIABILITY OF CENTRAL BLOOD PRESSURE: FINDINGS FROM THE INTERNATIONAL 24-HOUR AMBULATORY AORTIC BLOOD PRESSURE CONSORTIUM (I24ABC)
JO  - Artery Research
SP  - 109
EP  - 109
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.157
DO  - 10.1016/j.artres.2018.10.157
ID  - Weber2018
ER  -

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