Artery Research

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Volume 24, Issue C, December 2018, Pages 96 - 96

P61 ARTERIAL STIFFNESS IS ASSOCIATED WITH AORTIC VALVE CALCIFICATIONS

Authors
Dimitrios Terentes-Printzios1, Vasiliki Gardikioti1, Charalambos Vlachopoulos1, Konstantinos Toutouzas1, Maria Xanthopoulou1, Vasiliki Penesopoulou1, Georgios Latsios1, Vicky Tsigkou1, Charalambos Kalantzis1, Gerasimos Siasos1, Manolis Vavuranakis1, Dimitrios Tousoulis1
1Hypertension and Cardiometabolic Syndrome Unit, 1st Department of Cardiology, Medical School, National and Kapodistrian University of Athens, Hippokration Hospital, Athens, Greece
Available Online 4 December 2018.
DOI
10.1016/j.artres.2018.10.114How to use a DOI?
Abstract

Purpose/Background/Objective: Arterial stiffness and aortic hemodynamics are independent predictors of adverse cardiovascular events. Indications for Transcatheter Aortic Valve Implantation (TAVI) are increasing in number and Aortic Valve Calcifications (AVC) are an important prognostic factor of TAVI. We sought to investigate the associations between AVC and aortic vascular function/hemodynamics.

Methods: Fifty-two high-risk patients (mean age 80.4 ± 8.5 years, 27 male) with severe symptomatic aortic stenosis undergoing TAVI were included. Arterial stiffness was estimated through carotid-femoral pulse wave velocity (cfPWV) and brachial-ankle pulse wave velocity (baPWV). Aortic hemodynamics were also measured. Measurements were conducted prior to the implantation and at discharge. In all patients, a native and contrast-enhanced multislice cardiac computed tomography were performed pre-interventionally. AVC were then graded semi-quantitatively.

Results: Group 1 (subjects with none/mild AVC, n = 29) did not significantly differ on age, gender and body-mass index compared to group 2 (subjects with moderate/severe AVC, n = 23). From the traditional cardiovascular risk factors, only hypertension (p = 0.008), coronary artery disease (p = 0.016), atrial fibrillation (p = 0.075) and insulin-dependent diabetes mellitus (p = 0.068) were more statistically or showed a significant trend to be more prevalent in group 2. Group 2 had significantly higher both cfPWV and baPWV (8.3 ± 1.7 vs 7.2 ± 1.2 m/s and 1750 ± 484 cm/s vs. 2101 ± 590 cm/s with p = 0.008 and p = 0.022 respectively) compared to Group 1. (Figure) There was no difference in wave reflections indices between the two groups.

Conclusions: Our study shows that in patients with aortic stenosis there is a correlation between an increase in aortic stiffness and damage of aortic valvular leaflets as well as calcifications.

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<Previous Article In Issue
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Journal
Artery Research
Volume-Issue
24 - C
Pages
96 - 96
Publication Date
2018/12/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2018.10.114How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Dimitrios Terentes-Printzios
AU  - Vasiliki Gardikioti
AU  - Charalambos Vlachopoulos
AU  - Konstantinos Toutouzas
AU  - Maria Xanthopoulou
AU  - Vasiliki Penesopoulou
AU  - Georgios Latsios
AU  - Vicky Tsigkou
AU  - Charalambos Kalantzis
AU  - Gerasimos Siasos
AU  - Manolis Vavuranakis
AU  - Dimitrios Tousoulis
PY  - 2018
DA  - 2018/12/04
TI  - P61 ARTERIAL STIFFNESS IS ASSOCIATED WITH AORTIC VALVE CALCIFICATIONS
JO  - Artery Research
SP  - 96
EP  - 96
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.114
DO  - 10.1016/j.artres.2018.10.114
ID  - Terentes-Printzios2018
ER  -