Artery Research

Volume 24, Issue C, December 2018, Pages 92 - 93

P50 VALIDATION OF ULTRASOUND DETERMINATION OF LOCAL PULSE WAVE VELOCITY IN THE HUMAN ASCENDING AORTA AGAINST MRI MEASUREMENTS

Authors
Madalina Negoita1, Charlotte Manisty2, Anish Bhuva2, Alun Hughes2, Kim Parker3, Ashraf Khir1
1Brunel Institute of Bioengineering, Brunel University London, UK
2Institute of Cardiovascular Science, University College London, UK
3Department of Bioengineering, Imperial College London, UK
Available Online 4 December 2018.
DOI
10.1016/j.artres.2018.10.103How to use a DOI?
Abstract

Background: Pulse Wave Velocity (PWV) is a measure of arterial stiffness which predicts cardiovascular risk independently of blood pressure. Local PWV can be measured non-invasively in the ascending aorta of adults by means of Ultrasound (US), using successive recordings of Diameter (D) and the velocity (U) [1].

Aim: To test US measurements of local PWV in the ascending aorta of human adults against MRI measurements of local PWV.

Methods: PWV in the ascending aorta of 8 healthy volunteers (age 22–34 y, 3 females) was measured using a Siemens MAGNETOM Aera 1.5T MRI scanner as per standard protocols with cine and phase contrast imaging (sampling frequency 100 samples/cardiac cycle) and D and U were calculated using validated software [2]. US images were recorded using GE Vivid E95 scanner with a 1.5–4.5 MHz phased array transducer. PLAX was used for diameter recordings and A5CH for velocity. Measurements were recorded for 20 s during a breath-hold. D and U waveforms were extracted from each imaging modality to calculate PWV using the ln(D)U-loops technique [3].

Results: Average results are summarised in Table 1. The mean difference in PWV between MRI and US was 2.8 ± 0.3%.

Conclusions: PWV measured by US shows excellent agreement with MRI in the ascending aorta of adults. Given US availability, this technique offers an easy, affordable and non-invasive means of determining PWV and mechanical properties of the ascending aorta; thus, providing a tool for screening studies.

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Journal
Artery Research
Volume-Issue
24 - C
Pages
92 - 93
Publication Date
2018/12/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2018.10.103How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Madalina Negoita
AU  - Charlotte Manisty
AU  - Anish Bhuva
AU  - Alun Hughes
AU  - Kim Parker
AU  - Ashraf Khir
PY  - 2018
DA  - 2018/12/04
TI  - P50 VALIDATION OF ULTRASOUND DETERMINATION OF LOCAL PULSE WAVE VELOCITY IN THE HUMAN ASCENDING AORTA AGAINST MRI MEASUREMENTS
JO  - Artery Research
SP  - 92
EP  - 93
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.103
DO  - 10.1016/j.artres.2018.10.103
ID  - Negoita2018
ER  -