Artery Research

Volume 24, Issue C, December 2018, Pages 94 - 95

P56 CENTRAL PULSE PRESSURE IS ASSOCIATED WITH RETINAL ARTERIOLAR WALL THICKNESS AND WALL CROSS SECTIONAL AREA AS EVALUATED BY ADAPTIVE OPTICS

Authors
Antonio Gallo1, 2, Thomas Dietenbeck2, Nadjia Kachenoura2, Valérie Carreau3, Michel Paques4, Xavier Girerd3
1Cardiovascular Prevention Unit, University Hospital Pitié-Salpêtrière, Paris, France
2Sorbonne Université, INSERM, Laboratoire d’Imagerie Biomédicale, Paris, France
3Cardiovascular Prevention Unit, University Hospital Pitié-Salpêtrière, Paris, France
4Institut de la vision - Centre d’Investigation Clinique 503 Centre Hospitalier National des Quinze-Vingts, Assistance Publique-Hôpitaux de Paris, Paris, France
Available Online 4 December 2018.
DOI
10.1016/j.artres.2018.10.109How to use a DOI?
Abstract

Introduction: In 1991 Baumbach et al demonstrated taht pulse pressure (PP) but not mean arterial pressure (MAP) was correlated with pial arterioles wall cross-sectional area (WCSA)in rats. Adaptive optics (AO) allows a near-histological evaluation of retinal microcirculation (which shares the same embryological origins as the cerebral one) in a completely non-invasive fashion in humans. The aim of the study was to evaluate the relationship between PP/MAP and retinal arteriolar microcirculation.

Methods: Assessment included office BP measurements realized with SphygmoCor® with the patient resting in a supine position for at least 5 minutes followed by retinal microvascular analysis with AO RTX1® Camera to measure WT, internal diameter (ID), wall-to-lumen ratio (WLR) and WCSA, realized with the patients sitting in a stable position for at least 5 minutes.

Results: The study cohort consisted of 103 subjects on primary prevention and at intermediate risk, aged 20 to 80 years, with arterial hypertension and/or dyslipidemia. Study population was stratified according to median central PP (40 mmHg) and MAP (94 mmHg). Main results are shown in Table 1. Patients with a higher central PP showed an increased WT and WCSA. No difference was observed in WT and WCSA according to MAP.

Conclusions: Central PP is associated with structural changes in retinal microcirculation, namely a wall thickening and an increased vascular mass, as previously found on cerebral arterioles. Adaptive Optics allows a non-invasive evaluation of a microvascular territory which shares many morphological and physiological properties with the cerebral microcirculation, representing a promising tool for the prevention of cerebrovascular events.

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Journal
Artery Research
Volume-Issue
24 - C
Pages
94 - 95
Publication Date
2018/12/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2018.10.109How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Antonio Gallo
AU  - Thomas Dietenbeck
AU  - Nadjia Kachenoura
AU  - Valérie Carreau
AU  - Michel Paques
AU  - Xavier Girerd
PY  - 2018
DA  - 2018/12/04
TI  - P56 CENTRAL PULSE PRESSURE IS ASSOCIATED WITH RETINAL ARTERIOLAR WALL THICKNESS AND WALL CROSS SECTIONAL AREA AS EVALUATED BY ADAPTIVE OPTICS
JO  - Artery Research
SP  - 94
EP  - 95
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.109
DO  - 10.1016/j.artres.2018.10.109
ID  - Gallo2018
ER  -