Artery Research

Volume 24, Issue C, December 2018, Pages 88 - 88

P30 A 12-WEEK EXERCISE TRAINING PROGRAM REDUCES ENDOTHELIAL DAMAGE IN RESISTANT HYPERTENSION

Authors
Susana Lopes1, Catarina Garcia1, Ana Gonçalves2, Ilda Ribeiro3, Joana Barbosa de MElo3, Veronica Ribau4, Daniela Figueiredo5, João Viana6, Susana Bertoquini7, Jorge Polónia8, José Mesquita-Bsstos4, Alberto Alves9, Fernando Ribeiro1
1School of Health Sciences and Institute of Biomedicine - iBiMED, University of Aveiro, Aveiro, Portugal
2Center of Investigation on Environment Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, Center for Neuroscience and Cell Biology and Institute for Biomedical Imaging and Life Sciences (CNC.IBILI), Coimbra, Portugal
3Center of Investigation on Environment Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, Coimbra, POrtugal
4Cardiology Department, Hospital Infante D. Pedro, Centro Hospitalar do Baixo Vouga, Aveiro, Portugal
5School of Health Sciences and CINTESIS@UA, University of Aveiro, Aveiro, Portugal
6Sports Sciences, Health Sciences and Human Development, CIDESD, University Institute of Maia, Maia, Portugal
7Faculty of Medicine, University of Porto & Hypertension Unit, ULS Matosinhos, Porto, Portugal
8Faculty of Medicine, University of Porto & Hypertension Unit, ULS Matosinhos, Porto, Portugal
9Sports Sciences, Health Sciences and Human Development, CIDESD, University Institute of Maia, Maia, Portugal
Available Online 4 December 2018.
DOI
10.1016/j.artres.2018.10.083How to use a DOI?
Abstract

Background: Resistant Hypertension (RH) is associated with an increased risk of cardiovascular events and poor prognosis. Exercise training studies in RH patients have shown promising outcomes, nonetheless, none determine the impact of exercise on endothelial damage and repair. Circulating endothelial cells (CECs) are a reliable indicator of vascular damage and dysfunction. Recent studies in hypertension suggest that increased levels of endothelial progenitor cells (EPCs), a marker of endothelial repair, are related to increased CECs in order to compensate endothelial damage. Purpose: This study aimed to determine the effect of 12-week aerobic exercise program on the percentage of EPCs and CECs in RH patients.

Methods: Patients with RH were randomized to a 12-week aerobic exercise program (3 xs/week) (n = 13) and a usual care control group (n = 8). Outcome measures included clinical data, ambulatory blood pressure data and circulating levels of EPCs, hematopoietic stem cells (HSC) and CECs, quantified by flow cytometry. (ClinicalTrials.gov: NCT03090529).

Results: Baseline characteristics were similar between groups, including the number of antihypertensive drugs (5.0 ± 0.9 vs. 4.8 ± 0.7, p = 0.517). After 12 weeks, no significant changes were found in the levels of HSCs in both groups. The levels of CECs decreased in the exercise group [0.0073 (0.0016)% to 0.0058 (0.0029), p = 0.019]; no changes were observed in the control group. EPC’s decreased only in the exercise group [0.0071 (0.0027)% to 0.0052 (0.0037)%, p = 0.046].

Conclusions: Exercise training reduces endothelial injury/damage (reduced CECs levels) in RH patients, a specific group who is a challenge for clinicians as the available treatment options have reduced success.

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Journal
Artery Research
Volume-Issue
24 - C
Pages
88 - 88
Publication Date
2018/12/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2018.10.083How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Susana Lopes
AU  - Catarina Garcia
AU  - Ana Gonçalves
AU  - Ilda Ribeiro
AU  - Joana Barbosa de MElo
AU  - Veronica Ribau
AU  - Daniela Figueiredo
AU  - João Viana
AU  - Susana Bertoquini
AU  - Jorge Polónia
AU  - José Mesquita-Bsstos
AU  - Alberto Alves
AU  - Fernando Ribeiro
PY  - 2018
DA  - 2018/12/04
TI  - P30 A 12-WEEK EXERCISE TRAINING PROGRAM REDUCES ENDOTHELIAL DAMAGE IN RESISTANT HYPERTENSION
JO  - Artery Research
SP  - 88
EP  - 88
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.083
DO  - 10.1016/j.artres.2018.10.083
ID  - Lopes2018
ER  -