Artery Research

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Volume 24, Issue C, December 2018, Pages 87 - 87

P25 24-HOUR AORTIC AMBULATORY BLOOD PRESSURE IS BETTER ASSOCIATED WITH COMMON CAROTID ARTERY HYPERTROPHY THAN 24-HOUR BRACHIAL PRESSURE – THE SAFAR STUDY

Authors
Antonios Argyris1, Evaggelia Aissopou1, Efthymia Nasothymiou1, Theodoros Papaioannou2, Jacques Blacher3, Michel Safar3, Petros Sfikakis4, Athanase Protogerou1
1Cardiovascular Prevention and Research Unit, Pathophysiology Department, “Laiko” Hospital, National and Kapodistrian University of Athens, Athens, Greece
2Biomedical Engineering Unit, 1st Department of Cardiology, “Hippokration” Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece
3Paris Descartes University, AP-HP, Diagnosis and Therapeutic Center, Hôtel-Dieu, Paris, France
41st Department of Propaedeutic Medicine, “Laiko” Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece
Available Online 4 December 2018.
DOI
10.1016/j.artres.2018.10.078How to use a DOI?
Abstract

Objective: Evidence suggests the superiority of office aortic pressure over brachial on the evaluation of vascular damage and prognosis of cardiovascular disease (CVD); 24-hour ambulatory blood pressure monitoring (ABPM) is regarded the optimal method for assessing blood pressure (BP) profile. The non-invasive 24-hour aortic ABPM is feasible and superior to 24-hour brachial regarding the association with left ventricular hypertrophy and diastolic dysfunction. The aim of our study was to examine the association of 24-hour aortic and brachial ABPM with common carotid artery (CCA) hypertrophy.

Methods: Consecutive subjects referred for CVD risk assessment underwent 24-hour aortic and brachial ABPM using a validated oscillometric brachial cuff-based devise (Mobil-O-Graph). CCA hypertrophy was assessed by high-resolution ultrasound (assessment of intima media thickness - IMT).

Results: 497 subjects (aged 54 ± 13 years, 57% men, 80% hypertensives) were examined. Using Hotelling’s-Williams test it was shown that 24-hour aortic BP was significantly better correlated with IMT as compared with brachial BP (r: 0,254 vs. r: 0,202 for right IMT, r: 0,244 vs. r: 0,207 for left IMT, p < 0,05). Multivariate analysis (adjusted for possible confounders) revealed superiority of 24-hour aortic BP regarding the association with IMT as well as carotid hypertrophy. Last, in ROC analysis, aortic BP had a higher discriminatory ability compared to brachial for the detection of carotid hypertrophy (AUC: 0,707 vs. 0,656 for right carotid artery hypertrophy, AUC: 0,636 vs. 0,602 for left carotid artery hypertrophy, p < 0,05).

Conclusions: Non-invasively assessed 24-hour aortic pressure is more strongly associated with CCA IMT and provides a higher discriminatory ability for the detection of CCA hypertrophy.

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This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
24 - C
Pages
87 - 87
Publication Date
2018/12/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2018.10.078How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Antonios Argyris
AU  - Evaggelia Aissopou
AU  - Efthymia Nasothymiou
AU  - Theodoros Papaioannou
AU  - Jacques Blacher
AU  - Michel Safar
AU  - Petros Sfikakis
AU  - Athanase Protogerou
PY  - 2018
DA  - 2018/12/04
TI  - P25 24-HOUR AORTIC AMBULATORY BLOOD PRESSURE IS BETTER ASSOCIATED WITH COMMON CAROTID ARTERY HYPERTROPHY THAN 24-HOUR BRACHIAL PRESSURE – THE SAFAR STUDY
JO  - Artery Research
SP  - 87
EP  - 87
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.078
DO  - 10.1016/j.artres.2018.10.078
ID  - Argyris2018
ER  -