Artery Research

Volume 24, Issue C, December 2018, Pages 74 - 74

3.7 PULSE WAVE VELOCITY IS AN INDEPENDENT RISK FACTOR FOR CARDIOVASCULAR EVENTS, MORTALITY AND DECLINE IN RENAL FUNCTION IN PATIENTS WITH TYPE 1 DIABETES

Authors
Tine Willum Hansen1, Marie Frimodt-Møller1, Simone Theilade2, Nete Tofte2, Tarun Veer Singh Ahluwalia1, Peter Rossing3
1Steno Diabetes Center Copenhagen, Gentofte, Denmark
2Steno Diabetes Center Copenhagen, Gentofte, Denmark
3Steno Diabetes Center Copenhagen, University of Copenhagen, Gentofte, Denmark
Available Online 4 December 2018.
DOI
10.1016/j.artres.2018.10.038How to use a DOI?
Abstract

Purpose: The prognostic significance of carotid-femoral pulse wave velocity (cfPWV) remains to be determined in patients with type 1 diabetes (T1D). We investigated the predictive value of cfPWV for various endpoints in T1D.

Methods: At baseline, cfPWV was measured using the SphygmoCor device in 652 patients with T1D and various degrees of albuminuria. Endpoints were traced through National Registers and patient records and comprised: composite CVE, mortality, progression in albuminuria, and decline in estimated glomerular filtration rate (eGFR) ≥30%. Median follow-up ranged from 5.2 to 6.2 years. Slope estimates of eGFR and urinary albumin creatinine rate (UACR) were calculated for a median of 5.5 years. Adjustment included sex, age, mean arterial pressure, LDL cholesterol, smoking, HbA1c, UACR and eGFR at baseline. Hazard ratios (HR) were calculated per 1 standard derivation (SD) increase in cfPWV.

Results: Of the 652 participants (56% male); mean±SD age was 54 ± 13 years and cfPWV 10.5 ± 3.38 m/s2. After adjustment, higher cfPWV was significantly associated with all endpoints: composite CVE (n = 81; HR:1.31; p = 0.045); mortality (n = 48; HR:1.39; p = 0.033); progression in albuminuria (n = 31; HR:1.16; p = 0.012); and decline in eGFR ≥ 30% (n = 90; HR: 1.39; p = 0.015).Higher cfPWV was associated with a steeper decline in eGFR and a steeper increase in UACR after adjustments (p ≤ 0.009).

Conclusions: In patients with T1D, higher arterial stiffness was consistently associated with a higher risk of CVE, mortality and decline in renal function, independent of other risk factors. Measurement of cfPWV may have a promising role in risk stratification in T1D.

Open Access
This is an open access article distributed under the CC BY-NC license.

Journal
Artery Research
Volume-Issue
24 - C
Pages
74 - 74
Publication Date
2018/12/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2018.10.038How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Tine Willum Hansen
AU  - Marie Frimodt-Møller
AU  - Simone Theilade
AU  - Nete Tofte
AU  - Tarun Veer Singh Ahluwalia
AU  - Peter Rossing
PY  - 2018
DA  - 2018/12/04
TI  - 3.7 PULSE WAVE VELOCITY IS AN INDEPENDENT RISK FACTOR FOR CARDIOVASCULAR EVENTS, MORTALITY AND DECLINE IN RENAL FUNCTION IN PATIENTS WITH TYPE 1 DIABETES
JO  - Artery Research
SP  - 74
EP  - 74
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.038
DO  - 10.1016/j.artres.2018.10.038
ID  - Hansen2018
ER  -